UniProt Accession

 SEC13_MOUSE; Q9D1M0; Q99M12; Q9D712 

Genbank Protein ID

 AK003354; AK009755; BC002128 

Genbank Nucleotide ID

 BAB22732.1; BAB26480.1; AAH02128.1 

Protein Name

 Protein SEC13 homolog 

Protein Synonyms/Alias

 SEC13-like protein 1; SEC13-related protein 

Gene Name

 Sec13 

Gene Synonyms/Alias

 Sec13l1 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
38	CSSDRSVKIFDVRNG	acetylation	[1]
87	DRKVIIWKEENGTWE	ubiquitination	[2]
175	IDQPSGQKPNYIKKF	ubiquitination	[2]
181	QKPNYIKKFASGGCD	acetylation	[1]
181	QKPNYIKKFASGGCD	ubiquitination	[2]
192	GGCDNLIKLWREEED	acetylation	[1]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Functions as a component of the nuclear pore complex (NPC) and the COPII coat. At the endoplasmic reticulum, SEC13 is involved in the biogenesis of COPII-coated vesicles (By similarity). 

Sequence Annotation

 REPEAT 11 50 WD 1.
 REPEAT 55 96 WD 2.
 REPEAT 101 144 WD 3.
 REPEAT 148 204 WD 4.
 REPEAT 210 253 WD 5.
 REPEAT 260 299 WD 6.
 MOD_RES 2 2 N-acetylvaline (By similarity).
 MOD_RES 309 309 Phosphoserine (By similarity).  

Keyword

 Acetylation; Complete proteome; Cytoplasmic vesicle; Endoplasmic reticulum; ER-Golgi transport; Membrane; mRNA transport; Nuclear pore complex; Nucleus; Phosphoprotein; Protein transport; Reference proteome; Repeat; Translocation; Transport; WD repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 322 AA 

Protein Sequence

Gene Ontology

 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0012507; C:ER to Golgi transport vesicle membrane; IEA:UniProtKB-SubCell.
 GO:0000776; C:kinetochore; IEA:Compara.
 GO:0031080; C:nuclear pore outer ring; ISS:UniProtKB.
 GO:0006888; P:ER to Golgi vesicle-mediated transport; ISA:MGI.
 GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW. 

Interpro

 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR017986; WD40_repeat_dom. 

Pfam

 PF00400; WD40 

SMART

 SM00320; WD40 

PROSITE

 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 

PRINTS