CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019354
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Methyltransferase-like protein 2A 
Protein Synonyms/Alias
  
Gene Name
 METTL2A 
Gene Synonyms/Alias
 METTL2; HSPC266 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
16APAVLADKRQQFGSRubiquitination[1]
76DYEINAHKYWNDFYKubiquitination[1]
91IHENGFFKDRHWLFTubiquitination[1]
146EQHKCSSKSLEHKTQubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Probable S-adenosyl-L-methionine-dependent methyltransferase that mediates 3-methylcytidine modification of some tRNAs (By similarity). 
Sequence Annotation
 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 154 154 Phosphothreonine (By similarity).  
Keyword
 Acetylation; Alternative splicing; Complete proteome; Methyltransferase; Phosphoprotein; Reference proteome; S-adenosyl-L-methionine; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 378 AA 
Protein Sequence
MAGSYPEGAP AVLADKRQQF GSRFLRDPAR VFHHNAWDNV EWSEEQAAAA ERKVQENSIQ 60
RVCQEKQVDY EINAHKYWND FYKIHENGFF KDRHWLFTEF PELAPSQNQN HLKDWFLENK 120
SEVPECRNNE DGPGLIMEEQ HKCSSKSLEH KTQTLPVEEN VTQKISDLEI CADEFPGSSA 180
TYRILEVGCG VGNTVFPILQ TNNDPGLFVY CCDFSSTAIE LVQTNSEYDP SRCFAFVHDL 240
CDEEKSYPVP KGSLDIIILI FVLSAIVPDK MQKAINRLSR LLKPGGMMLL RDYGRYDMAQ 300
LRFKKGQCLS GNFYVRGDGT RVYFFTQEEL DTLFTTAGLE KVQNLVDRRL QVNRGKQLTM 360
YRVWIQCKYC KPLLSSTS 378 
Gene Ontology
 GO:0016427; F:tRNA (cytosine) methyltransferase activity; ISS:UniProtKB. 
Interpro
 IPR026113; MeTrfase. 
Pfam
  
SMART
  
PROSITE
  
PRINTS