| Tag | Content |
|---|
| CPLM ID | CPLM-010631 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Proteasome activator complex subunit 1 |
Protein Synonyms/Alias | 11S regulator complex subunit alpha; REG-alpha; Activator of multicatalytic protease subunit 1; Proteasome activator 28 subunit alpha; PA28a; PA28alpha |
Gene Name | Psme1 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 13 | VHPEAQAKVDVFRED | ubiquitination | [1] | | 35 | LLGSYFPKKISELDA | ubiquitination | [1] | | 70 | IPVPDPVKEKEKEER | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome. |
Sequence Annotation | |
Keyword | Complete proteome; Proteasome; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 249 AA |
Protein Sequence | MATLRVHPEA QAKVDVFRED LCSKTENLLG SYFPKKISEL DAFLKEPALN EANLSNLKAP 60
LDIPVPDPVK EKEKEERKKQ QEKEEKEEKK KGDEDDKGPP CGPVNCNEKI VVLLQRLKPE 120
IKDVTEQLNL VTTWLQLQIP RIEDGNNFGV AVQEKVFELM TNLHTKLEGF HTQISKYFSE 180
RGDAVAKAAK QPHVGDYRQL VHELDEAEYQ EIRLMVMEIR NAYAVLYDII LKNFEKLKKP 240
RGETKGMIY 249 |
Gene Ontology | GO:0008537; C:proteasome activator complex; IEA:InterPro. GO:0061133; F:endopeptidase activator activity; IPI:MGI. GO:0019884; P:antigen processing and presentation of exogenous antigen; IMP:MGI. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |