UniProt Accession

 RET4_HUMAN; P02753; D3DR38; O43478; O43479; Q5VY24; Q8WWA3; Q9P178 

Genbank Protein ID

 X00129; AL356214; CH471066; CH471066; CH471066; BC020633; X02775; X02824; AF119868; AF025334; AF025335 

Genbank Nucleotide ID

 CAA24959.1; CAH72328.1; EAW50065.1; EAW50066.1; EAW50067.1; AAH20633.1; CAA26553.1; CAB46489.1; AAF69622.1; AAC02945.1; AAC02946.1 

Protein Name

 Retinol-binding protein 4 

Protein Synonyms/Alias

 Plasma retinol-binding protein; PRBP; RBP; Plasma retinol-binding protein(1-182); Plasma retinol-binding protein(1-181); Plasma retinol-binding protein(1-179); Plasma retinol-binding protein(1-176) 

Gene Name

 RBP4 

Gene Synonyms/Alias

 PRO2222 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
2	******MKWVWALLL	acetylation	[1]
30	RVSSFRVKENFDKAR	acetylation	[1]
35	RVKENFDKARFSGTW	acetylation	[1]
47	GTWYAMAKKDPEGLF	acetylation	[1]
48	TWYAMAKKDPEGLFL	acetylation	[1]
76	GQMSATAKGRVRLLN	acetylation	[1]
103	TDTEDPAKFKMKYWG	acetylation	[1]
105	TEDPAKFKMKYWGVA	acetylation	[1]
107	DPAKFKMKYWGVASF	acetylation	[1]
117	GVASFLQKGNDDHWI	acetylation	[1]
168	GLPPEAQKIVRQRQE	acetylation	[1]

Reference

 [1] Involvement of tyrosine and lysine residues of retinol-binding protein in the interaction between retinol and retinol-binding protein and between retinol-binding protein and prealbumin. Acetylation with N-acetylimidazole and alkaline titration.
 Heller J, Horwitz J.
 J Biol Chem. 1975 Apr 25;250(8):3019-23. [PMID: 235536] 

Functional Description

 Delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin, this prevents its loss by filtration through the kidney glomeruli. 

Sequence Annotation

 DISULFID 22 178
 DISULFID 88 192
 DISULFID 138 147  

Keyword

 3D-structure; Complete proteome; Direct protein sequencing; Disease mutation; Disulfide bond; Reference proteome; Retinol-binding; Secreted; Sensory transduction; Signal; Transport; Vision; Vitamin A. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 201 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005615; C:extracellular space; IDA:BHF-UCL.
 GO:0043234; C:protein complex; IEA:Compara.
 GO:0016918; F:retinal binding; IEA:UniProtKB-KW.
 GO:0019841; F:retinol binding; IDA:BHF-UCL.
 GO:0034632; F:retinol transporter activity; IC:BHF-UCL.
 GO:0048738; P:cardiac muscle tissue development; ISS:BHF-UCL.
 GO:0050908; P:detection of light stimulus involved in visual perception; IEA:Compara.
 GO:0048562; P:embryonic organ morphogenesis; ISS:BHF-UCL.
 GO:0060059; P:embryonic retina morphogenesis in camera-type eye; ISS:BHF-UCL.
 GO:0048706; P:embryonic skeletal system development; ISS:BHF-UCL.
 GO:0048807; P:female genitalia morphogenesis; ISS:BHF-UCL.
 GO:0006094; P:gluconeogenesis; IMP:BHF-UCL.
 GO:0042593; P:glucose homeostasis; IDA:BHF-UCL.
 GO:0060347; P:heart trabecula formation; ISS:BHF-UCL.
 GO:0030324; P:lung development; ISS:BHF-UCL.
 GO:0030277; P:maintenance of gastrointestinal epithelium; IDA:BHF-UCL.
 GO:0008584; P:male gonad development; IEA:Compara.
 GO:0060044; P:negative regulation of cardiac muscle cell proliferation; ISS:BHF-UCL.
 GO:0007603; P:phototransduction, visible light; TAS:Reactome.
 GO:0051024; P:positive regulation of immunoglobulin secretion; ISS:BHF-UCL.
 GO:0032024; P:positive regulation of insulin secretion; IMP:BHF-UCL.
 GO:0045471; P:response to ethanol; IEA:Compara.
 GO:0032868; P:response to insulin stimulus; IEA:Compara.
 GO:0032526; P:response to retinoic acid; IDA:BHF-UCL.
 GO:0042574; P:retinal metabolic process; IEA:Compara.
 GO:0042572; P:retinol metabolic process; IMP:BHF-UCL.
 GO:0007283; P:spermatogenesis; IEA:Compara.
 GO:0060157; P:urinary bladder development; ISS:BHF-UCL.
 GO:0060065; P:uterus development; ISS:BHF-UCL.
 GO:0060068; P:vagina development; ISS:BHF-UCL. 

Interpro

 IPR012674; Calycin.
 IPR011038; Calycin-like.
 IPR002345; Lipocalin.
 IPR022271; Lipocalin_ApoD.
 IPR022272; Lipocalin_CS.
 IPR000566; Lipocln_cytosolic_FA-bd_dom.
 IPR002449; Retinol-bd/Purpurin. 

Pfam

 PF00061; Lipocalin 

SMART

  

PROSITE

 PS00213; LIPOCALIN 

PRINTS

 PR00179; LIPOCALIN.
 PR01174; RETINOLBNDNG.