CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024780
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 FERM, RhoGEF and pleckstrin domain-containing protein 1 
Protein Synonyms/Alias
  
Gene Name
 Farp1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
549DKAYYIAKEVSTTERubiquitination[1]
772IRLGSLSKLSGKGLQubiquitination[1]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
 May play a role in semaphorin signaling (By similarity). Functions as guanine nucleotide exchange factor for RAC1. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses. 
Sequence Annotation
 DOMAIN 40 320 FERM.
 DOMAIN 543 734 DH.
 DOMAIN 763 860 PH 1.
 DOMAIN 936 1033 PH 2.
 MOD_RES 24 24 Phosphothreonine (By similarity).
 MOD_RES 340 340 Phosphoserine (By similarity).
 MOD_RES 427 427 Phosphoserine (By similarity).
 MOD_RES 513 513 Phosphoserine (By similarity).
 MOD_RES 517 517 Phosphoserine (By similarity).
 MOD_RES 876 876 Phosphoserine (By similarity).
 MOD_RES 893 893 Phosphoserine (By similarity).  
Keyword
 Cell junction; Cell membrane; Cell projection; Complete proteome; Cytoplasm; Developmental protein; Guanine-nucleotide releasing factor; Membrane; Phosphoprotein; Reference proteome; Repeat; Synapse; Synaptosome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1049 AA 
Protein Sequence
MGEIEQKPTP ASRLGAPENS GISTLERGQK PPPTPSGKLM TVKIQMLDDT QEAFEVPQRA 60
PGKVLFDAVC NHLNLVEGDY FGLEFPDHRK IVVWLDLLKP IVKQIRRPKH VLVKFVVKFF 120
PPDHTQLQEE LTRYLFALQV KQDLAQGRLT CNDTSAALLI SHIVQSEIGD FDEALDREHL 180
AKNKYVPQQD ALEDKIVEFH HSHIGQTPAE SDFQLLEVAR RLEMYGIRLH PAKDREGTKI 240
NLAVANTGIL VFQGFTKINA FNWAKVRKLS FKRKRFLIKL RPDVNSSYQD TLEFLMAGRD 300
FCKSFWKICV EHHAFFRLFE EPKPKPKPVL FSRGSSFRFS GRTQKQVLDY VKEGGHKKVQ 360
FERKHSKIHS TRSLVSQPTA PNSEVPKQSP QSASLTFGEG TESPSAQSCQ QAKETKVCTL 420
EPGPRQSPAL SKSPSGSKAA DGTAAAAPPE EEDEEEGGKD GIRPSNPQPP QPSTGSLTGS 480
PHLSELSINS QGGAAPANVT LSPNLSPDNK QASPLISPLL NDQACPRTDD EEEGRRKRFP 540
TDKAYYIAKE VSTTERTYLK DLEVIASWFQ STVSKEDSMP EALKSLIFPN FEPLHKFHTN 600
FLKEIEQRLA LWEGRSNAHI RGDYQRIGDV MLKNIQGMKH LAAHLWKHSE ALEALETSIK 660
GSRRLEHFCR DFELQKVCYL PLNTFLLRPL HRLMHYKQVL ERLCKHHPPN HADFRDCRAA 720
LAEITEMVAQ LHGTMIKMEN FQKLHELKKD LIGIDNLVIP GREFIRLGSL SKLSGKGLQQ 780
RMFFLFNDVL LYTSRGLTAS NQFKVHGQLP LYGMTIEESE EEWGVPHCLT LRGQRQSIIV 840
AASSRSEMEK WLEDIQMAID LAEKSNGPTP ELLASSPPDN KSPDEATAAD QESEDDLSAS 900
RTSLERQAPH RGNTMVHVCW HRSTSVSMVD FSIAVENQLS GNLLRKFKNS NGWQKLWVVF 960
TNFCLFFYKS HQDSHPLASL PLLGYSLTIP SESENIHKDY VFKLHFKSHV YYFRAESEYT 1020
FERWMEVIRS ATSSASRAHS LSHKESHLY 1049 
Gene Ontology
 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0005856; C:cytoskeleton; IEA:InterPro.
 GO:0005829; C:cytosol; IDA:UniProtKB.
 GO:0030425; C:dendrite; IDA:UniProtKB.
 GO:0043197; C:dendritic spine; IEA:UniProtKB-SubCell.
 GO:0031234; C:extrinsic to internal side of plasma membrane; IDA:UniProtKB.
 GO:0030175; C:filopodium; IEA:UniProtKB-SubCell.
 GO:0045202; C:synapse; IEA:UniProtKB-SubCell.
 GO:0005543; F:phospholipid binding; IEA:InterPro.
 GO:0030676; F:Rac guanyl-nucleotide exchange factor activity; IMP:UniProtKB.
 GO:0048813; P:dendrite morphogenesis; IMP:UniProtKB.
 GO:0010923; P:negative regulation of phosphatase activity; IEA:Compara.
 GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
 GO:0007416; P:synapse assembly; IMP:UniProtKB. 
Interpro
 IPR019749; Band_41_domain.
 IPR019750; Band_41_fam.
 IPR000219; DH-domain.
 IPR000798; Ez/rad/moesin_like.
 IPR014847; FERM-adjacent.
 IPR014352; FERM/acyl-CoA-bd_prot_3-hlx.
 IPR019748; FERM_central.
 IPR019747; FERM_CS.
 IPR000299; FERM_domain.
 IPR018979; FERM_N.
 IPR018980; FERM_PH-like_C.
 IPR011993; PH_like_dom.
 IPR001849; Pleckstrin_homology. 
Pfam
 PF08736; FA
 PF09380; FERM_C
 PF00373; FERM_M
 PF09379; FERM_N
 PF00169; PH
 PF00621; RhoGEF 
SMART
 SM00295; B41
 SM00233; PH
 SM00325; RhoGEF 
PROSITE
 PS00741; DH_1
 PS50010; DH_2
 PS00660; FERM_1
 PS00661; FERM_2
 PS50057; FERM_3
 PS50003; PH_DOMAIN 
PRINTS
 PR00935; BAND41.
 PR00661; ERMFAMILY.