CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004577
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 T-cell acute lymphocytic leukemia protein 1 
Protein Synonyms/Alias
 TAL-1; Class A basic helix-loop-helix protein 17; bHLHa17; Stem cell protein; T-cell leukemia/lymphoma protein 5 
Gene Name
 TAL1 
Gene Synonyms/Alias
 BHLHA17; SCL; TCL5 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
221IPTHPPDKKLSKNEIacetylation[1]
222PTHPPDKKLSKNEILacetylation[1, 2]
225PPDKKLSKNEILRLAacetylation[2]
Reference
 [1] P/CAF-mediated acetylation regulates the function of the basic helix-loop-helix transcription factor TAL1/SCL.
 Huang S, Qiu Y, Shi Y, Xu Z, Brandt SJ.
 EMBO J. 2000 Dec 15;19(24):6792-803. [PMID: 11118214]
 [2] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
 Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation (By similarity). 
Sequence Annotation
 DOMAIN 187 239 bHLH.
 MOD_RES 122 122 Phosphoserine.  
Keyword
 Alternative splicing; Chromosomal rearrangement; Complete proteome; Developmental protein; Differentiation; DNA-binding; Nucleus; Phosphoprotein; Proto-oncogene; Reference proteome; Transcription; Transcription regulation; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 331 AA 
Protein Sequence
MTERPPSEAA RSDPQLEGRD AAEASMAPPH LVLLNGVAKE TSRAAAAEPP VIELGARGGP 60
GGGPAGGGGA ARDLKGRDAA TAEARHRVPT TELCRPPGPA PAPAPASVTA ELPGDGRMVQ 120
LSPPALAAPA APGRALLYSL SQPLASLGSG FFGEPDAFPM FTTNNRVKRR PSPYEMEITD 180
GPHTKVVRRI FTNSRERWRQ QNVNGAFAEL RKLIPTHPPD KKLSKNEILR LAMKYINFLA 240
KLLNDQEEEG TQRAKTGKDP VVGAGGGGGG GGGGAPPDDL LQDVLSPNSS CGSSLDGAAS 300
PDSYTEEPAP KHTARSLHPA MLPAADGAGP R 331 
Gene Ontology
 GO:0000790; C:nuclear chromatin; IDA:BHF-UCL.
 GO:0005667; C:transcription factor complex; IDA:BHF-UCL.
 GO:0003682; F:chromatin binding; IDA:MGI.
 GO:0070888; F:E-box binding; IDA:BHF-UCL.
 GO:0000980; F:RNA polymerase II distal enhancer sequence-specific DNA binding; IEA:Compara.
 GO:0000981; F:sequence-specific DNA binding RNA polymerase II transcription factor activity; IEA:Compara.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IDA:BHF-UCL.
 GO:0001525; P:angiogenesis; IEA:Compara.
 GO:0060018; P:astrocyte fate commitment; IEA:Compara.
 GO:0030221; P:basophil differentiation; IEP:BHF-UCL.
 GO:0045165; P:cell fate commitment; ISS:BHF-UCL.
 GO:0060216; P:definitive hemopoiesis; IEA:Compara.
 GO:0035162; P:embryonic hemopoiesis; ISS:UniProtKB.
 GO:0030218; P:erythrocyte differentiation; IMP:BHF-UCL.
 GO:0043249; P:erythrocyte maturation; IEA:Compara.
 GO:0060217; P:hemangioblast cell differentiation; IEA:Compara.
 GO:0060218; P:hematopoietic stem cell differentiation; IEA:Compara.
 GO:0007626; P:locomotory behavior; IEA:Compara.
 GO:0035855; P:megakaryocyte development; IEA:Compara.
 GO:0030219; P:megakaryocyte differentiation; IEP:BHF-UCL.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0030220; P:platelet formation; IEA:Compara.
 GO:0051781; P:positive regulation of cell division; IMP:BHF-UCL.
 GO:0045799; P:positive regulation of chromatin assembly or disassembly; IMP:BHF-UCL.
 GO:0045648; P:positive regulation of erythrocyte differentiation; IDA:UniProtKB.
 GO:0045931; P:positive regulation of mitotic cell cycle; IMP:BHF-UCL.
 GO:0031334; P:positive regulation of protein complex assembly; IDA:BHF-UCL.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL.
 GO:0042127; P:regulation of cell proliferation; IEA:Compara.
 GO:0060375; P:regulation of mast cell differentiation; IEA:Compara.
 GO:2000036; P:regulation of stem cell maintenance; IEA:Compara.
 GO:0021527; P:spinal cord association neuron differentiation; IEA:Compara. 
Interpro
 IPR011598; bHLH_dom. 
Pfam
 PF00010; HLH 
SMART
 SM00353; HLH 
PROSITE
 PS50888; BHLH 
PRINTS