UniProt Accession

 RN212_HUMAN; Q495C1; C9J8N0; Q495C0; Q86W82; Q8IY99; Q8N8U7 

Genbank Protein ID

 AK096160; AC019103; AC092535; BC036250; BC050356; BC101258; BC101259; BC101260; BC101261 

Genbank Nucleotide ID

 BAC04714.1; AAH36250.2; AAH50356.2; AAI01259.1; AAI01260.1; AAI01261.1; AAI01262.1 

Protein Name

 Probable E3 SUMO-protein ligase RNF212 

Protein Synonyms/Alias

 RING finger protein 212 

Gene Name

 RNF212 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
101	LLAFYREKISRLEES	ubiquitination	[1, 2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Key regulator of crossing-over during meiosis: required to couple chromosome synapsis to the formation of crossover- specific recombination complexes. Localizes to recombination sites and stabilizes meiosis-specific recombination factors, such as MutS-gamma complex proteins (MSH4 and MSH5) and TEX11. May act as a SUMO E3 ligase that mediates sumoylation of target proteins MSH4 and/or MSH5, leading to enhance their binding to recombination sites. Acts as a limiting factor for crossover designation and/or reinforcement (By similarity). 

Sequence Annotation

 ZN_FING 7 46 RING-type.  

Keyword

 Alternative splicing; Chromosome; Coiled coil; Complete proteome; Ligase; Meiosis; Metal-binding; Nucleus; Polymorphism; Reference proteome; Ubl conjugation pathway; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 297 AA 

Protein Sequence

Gene Ontology

 GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006311; P:meiotic gene conversion; ISS:UniProtKB.
 GO:0016925; P:protein sumoylation; IEA:UniProtKB-UniPathway.
 GO:0007131; P:reciprocal meiotic recombination; ISS:UniProtKB. 

Interpro

 IPR001841; Znf_RING.
 IPR017907; Znf_RING_CS. 

Pfam

  

SMART

 SM00184; RING 

PROSITE

 PS00518; ZF_RING_1
 PS50089; ZF_RING_2 

PRINTS