CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022402
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Zinc finger protein 226 
Protein Synonyms/Alias
  
Gene Name
 ZNF226 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
53SVGHPPFKQDVSPIEubiquitination[1, 2, 3]
85LGEKNQSKLITVQDRubiquitination[2]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
 May be involved in transcriptional regulation. 
Sequence Annotation
 DOMAIN 8 78 KRAB.
 ZN_FING 252 274 C2H2-type 1; degenerate.
 ZN_FING 280 302 C2H2-type 2; degenerate.
 ZN_FING 307 329 C2H2-type 3.
 ZN_FING 335 357 C2H2-type 4.
 ZN_FING 363 385 C2H2-type 5.
 ZN_FING 391 413 C2H2-type 6.
 ZN_FING 419 441 C2H2-type 7.
 ZN_FING 447 469 C2H2-type 8.
 ZN_FING 475 497 C2H2-type 9.
 ZN_FING 503 525 C2H2-type 10.
 ZN_FING 531 553 C2H2-type 11.
 ZN_FING 559 581 C2H2-type 12.
 ZN_FING 587 609 C2H2-type 13.
 ZN_FING 615 637 C2H2-type 14.
 ZN_FING 643 665 C2H2-type 15.
 ZN_FING 671 693 C2H2-type 16.
 ZN_FING 699 721 C2H2-type 17.
 ZN_FING 727 749 C2H2-type 18.
 ZN_FING 755 777 C2H2-type 19.  
Keyword
 Alternative splicing; Complete proteome; DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 803 AA 
Protein Sequence
MNMFKEAVTF KDVAVAFTEE ELGLLGPAQR KLYRDVMVEN FRNLLSVGHP PFKQDVSPIE 60
RNEQLWIMTT ATRRQGNLGE KNQSKLITVQ DRESEEELSC WQIWQQIAND LTRCQDSMIN 120
NSQCHKQGDF PYQVGTELSI QISEDENYIV NKADGPNNTG NPEFPILRTQ DSWRKTFLTE 180
SQRLNRDQQI SIKNKLCQCK KGVDPIGWIS HHDGHRVHKS EKSYRPNDYE KDNMKILTFD 240
HNSMIHTGQK SYQCNECKKP FSDLSSFDLH QQLQSGEKSL TCVERGKGFC YSPVLPVHQK 300
VHVGEKLKCD ECGKEFSQGA HLQTHQKVHV IEKPYKCKQC GKGFSRRSAL NVHCKVHTAE 360
KPYNCEECGR AFSQASHLQD HQRLHTGEKP FKCDACGKSF SRNSHLQSHQ RVHTGEKPYK 420
CEECGKGFIC SSNLYIHQRV HTGEKPYKCE ECGKGFSRPS SLQAHQGVHT GEKSYICTVC 480
GKGFTLSSNL QAHQRVHTGE KPYKCNECGK SFRRNSHYQV HLVVHTGEKP YKCEICGKGF 540
SQSSYLQIHQ KAHSIEKPFK CEECGQGFNQ SSRLQIHQLI HTGEKPYKCE ECGKGFSRRA 600
DLKIHCRIHT GEKPYNCEEC GKVFRQASNL LAHQRVHSGE KPFKCEECGK SFGRSAHLQA 660
HQKVHTGDKP YKCDECGKGF KWSLNLDMHQ RVHTGEKPYK CGECGKYFSQ ASSLQLHQSV 720
HTGEKPYKCD VCGKVFSRSS QLQSHQRVHT GEKPYKCEIC GKSFSWRSNL TVHHRIHVGD 780
KSYKSNRGGK NIRESTQEKK SIK 803 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR001909; Krueppel-associated_box.
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 
Pfam
 PF01352; KRAB
 PF00096; zf-C2H2 
SMART
 SM00349; KRAB
 SM00355; ZnF_C2H2 
PROSITE
 PS50805; KRAB
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 
PRINTS