UniProt Accession

 ZC12A_HUMAN; Q5D1E8; D3DPT0; Q6I9Z1; Q9H5P1 

Genbank Protein ID

 AY920403; AK026884; CR457364; AL034379; AL449284; AL449284; AL034379; CH471059; CH471059; BC005001 

Genbank Nucleotide ID

 AAX14017.1; BAB15581.1; CAG33645.1; CAI20551.1; CAI20551.1; CAH73689.1; CAH73689.1; EAX07346.1; EAX07347.1; AAH05001.1 

Protein Name

 Ribonuclease ZC3H12A 

Protein Synonyms/Alias

 MCP-induced protein 1; Zinc finger CCCH domain-containing protein 12A 

Gene Name

 ZC3H12A 

Gene Synonyms/Alias

 MCPIP; MCPIP1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
57	MKVDFFRKLGYSSTE	ubiquitination	[1]
551	GRAGSLAKEQASVYT	ubiquitination	[2]

Reference

 [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Has RNase activity and selectively degrades specific target mRNA species. Modulates the immune response and inflammation by regulating the decay of specific mRNA molecules. Recognizes the 3'-untranslated region (UTR) of the mRNA for IL6, CALCR and IL12B. Required for normal decay of IL6 mRNA (By similarity). Triggers apoptosis and promotes angiogenesis in response to the binding of CCL2 to CCR2. Regulates expression of CDH12 and CHD19. 

Sequence Annotation

 ZN_FING 301 324 C3H1-type.
 REGION 112 297 RNase.
 REGION 214 220 RNA binding (Probable).
 METAL 226 226 Magnesium.  

Keyword

 3D-structure; Angiogenesis; Apoptosis; Complete proteome; Cytoplasm; Developmental protein; Differentiation; Endonuclease; Hydrolase; Magnesium; Metal-binding; Nuclease; Nucleus; Polymorphism; Reference proteome; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 599 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:BHF-UCL.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0005886; C:plasma membrane; IDA:HPA.
 GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.
 GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
 GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
 GO:0071222; P:cellular response to lipopolysaccharide; IDA:BHF-UCL.
 GO:0010629; P:negative regulation of gene expression; IDA:BHF-UCL.
 GO:0032715; P:negative regulation of interleukin-6 production; IDA:BHF-UCL.
 GO:0043031; P:negative regulation of macrophage activation; IC:BHF-UCL.
 GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; IDA:BHF-UCL.
 GO:0045019; P:negative regulation of nitric oxide biosynthetic process; IDA:BHF-UCL.
 GO:0032720; P:negative regulation of tumor necrosis factor production; IDA:BHF-UCL.
 GO:0090305; P:nucleic acid phosphodiester bond hydrolysis; IEA:GOC.
 GO:0010508; P:positive regulation of autophagy; IDA:BHF-UCL.
 GO:0045600; P:positive regulation of fat cell differentiation; IDA:BHF-UCL.
 GO:0010628; P:positive regulation of gene expression; IDA:BHF-UCL.
 GO:0010884; P:positive regulation of lipid storage; IDA:BHF-UCL.
 GO:2000379; P:positive regulation of reactive oxygen species metabolic process; IDA:BHF-UCL. 

Interpro

 IPR021869; RNase_Zc3h12. 

Pfam

 PF11977; RNase_Zc3h12a 

SMART

  

PROSITE

 PS50103; ZF_C3H1 

PRINTS