| Tag | Content |
|---|
| CPLM ID | CPLM-018766 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | ER degradation-enhancing alpha-mannosidase-like protein 1 |
Protein Synonyms/Alias | |
Gene Name | Edem1 |
Gene Synonyms/Alias | Edem |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 274 | LPAFENTKTGIPYPR | ubiquitination | [1] | | 638 | RRYSLPLKSIYMRQI | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle. It is directly involved in endoplasmic reticulum-associated degradation (ERAD) and targets misfolded glycoproteins for degradation in an N-glycan-independent manner, probably by forming a complex with SEL1L. It lacks mannosidase activity. |
Sequence Annotation | CARBOHYD 176 176 N-linked (GlcNAc...) (Potential).
CARBOHYD 193 193 N-linked (GlcNAc...) (Potential).
CARBOHYD 294 294 N-linked (GlcNAc...) (Potential).
CARBOHYD 337 337 N-linked (GlcNAc...) (Potential). |
Keyword | Complete proteome; Endoplasmic reticulum; Glycoprotein; Membrane; Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix; Unfolded protein response. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 652 AA |
Protein Sequence | MQWRALVLGL VLLRLGLHAV LWLVFGLGPS MGFYQRFPLS FGFQRLRDPD GSGPVGPPGG 60
PAWLHRPRRG TEGRLETPPE PGPTPGPGVC GPAHWGYALG GGGCGPDEYE RRYSGAFPPQ 120
LRAQMRDLAR GMFVFGYDNY MAHAFPQDEL NPIYCRGRGP DRGDPSNLNI NDVLGNYSLT 180
LVDALDTLAI MGNSSEFQKA VKLVINTVSF DKDSTVQVFE ATIRVLGSLL SAHRIITDSK 240
QPFGDMTIED YDNELLYMAH DLAVRLLPAF ENTKTGIPYP RVNLKTGVPP DSNNETCTAG 300
AGSLLVEFGI LSRLLGDSTF EWVARRAVKA LWNLRSNDTG LLGNVVNIQT GHWVGKQSGL 360
GAGLDSFYEY LLKSYILFGE KEDLEMFNAA YQSIQSYLRR GREACNEGEG DPPLYVNVNM 420
FSGQLMNTWI DSLQAFFPGL QVLIGDVEDA ICLHAFYYAI WKRYGALPER YNWQLQAPDV 480
LFYPLRPELV ESTYLLYQAT KNPFYLHVGM DILQSLEKYT KVKCGYATLH HVIDKSKEDR 540
MESFFLSETC KYLYLLFDEE NPVHKSGTRY MFTTEGHIIS VDKRLRELPW KEFFSEDGER 600
DQEEKFVHRP KSQELRVINS SSNCNRVPDE RRYSLPLKSI YMRQIDQMVG LI 652 |
Gene Ontology | GO:0030176; C:integral to endoplasmic reticulum membrane; IDA:MGI. GO:0005509; F:calcium ion binding; IEA:InterPro. GO:0051787; F:misfolded protein binding; ISS:UniProtKB. GO:0030433; P:ER-associated protein catabolic process; IDA:MGI. GO:0006986; P:response to unfolded protein; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |