| Tag | Content |
|---|
| CPLM ID | CPLM-021053 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Solute carrier family 23 member 2 |
Protein Synonyms/Alias | Na(+)/L-ascorbic acid transporter 2; Sodium-dependent vitamin C transporter 2; SVCT-2; mSVCT2; Yolk sac permease-like molecule 2 |
Gene Name | Slc23a2 |
Gene Synonyms/Alias | Kiaa0238; Svct2; Yspl2 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 22 | AGGSTEGKYEEEAKH | ubiquitination | [1] | | 296 | KFPLPIYKSKKGWTA | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate (By similarity). |
Sequence Annotation | MOD_RES 78 78 Phosphoserine.
MOD_RES 79 79 Phosphothreonine.
MOD_RES 81 81 Phosphoserine.
MOD_RES 647 647 Phosphothreonine.
CARBOHYD 188 188 N-linked (GlcNAc...) (Potential).
CARBOHYD 196 196 N-linked (GlcNAc...) (Potential). |
Keyword | Alternative splicing; Cell membrane; Complete proteome; Glycoprotein; Ion transport; Membrane; Phosphoprotein; Reference proteome; Sodium; Sodium transport; Symport; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 648 AA |
Protein Sequence | MMGIGKNTAS KSVEAGGSTE GKYEEEAKHS NFFTLPVVIN GGATSSGEQD NEDTELMAIY 60
TTENGIAEKS SLAETLDSTG SLDPQRSDMI YTIEDVPPWY LCIFLGLQHY LTCFSGTIAV 120
PFLLADAMCV GDDQWATSQL IGTIFFCVGI TTLLQTTFGC RLPLFQASAF AFLAPARAIL 180
SLDKWKCNTT EITVANGTAE LLEHIWHPRI QEIQGAIIMS SLIEVVIGLL GLPGALLRYI 240
GPLTITPTVA LIGLSGFQAA GERAGKHWGI AMLTIFLVLL FSQYARNVKF PLPIYKSKKG 300
WTAYKFQLFK MFPIILAILV SWLLCFIFTV TDVFPSNSTD YGYYARTDAR KGVLLVAPWF 360
KVPYPFQWGM PTVSAAGVIG MLSAVVASII ESIGDYYACA RLSCAPPPPI HAINRGIFVE 420
GLSCVLDGIF GTGNGSTSSS PNIGVLGITK VGSRRVIQYG AALMLGLGMV GKFSALFASL 480
PDPVLGALFC TLFGMITAVG LSNLQFIDLN SSRNLFVLGF SIFFGLVLPS YLRQNPLVTG 540
ITGIDQILNV LLTTAMFVGG CVAFILDNTI PGTPEERGIK KWKKGVSKGS KSLDGMESYN 600
LPFGMNIIKK YRCFSYLPIS PTFAGYTWKG FGKSENSRSS DKDSQATV 648 |
Gene Ontology | GO:0016324; C:apical plasma membrane; IEA:Compara. GO:0009925; C:basal plasma membrane; IDA:UniProtKB. GO:0005737; C:cytoplasm; IDA:UniProtKB. GO:0005887; C:integral to plasma membrane; IEA:Compara. GO:0008520; F:L-ascorbate:sodium symporter activity; IMP:MGI. GO:0015229; F:L-ascorbic acid transporter activity; IDA:UniProtKB. GO:0070890; F:sodium-dependent L-ascorbate transmembrane transporter activity; IEA:Compara. GO:0019852; P:L-ascorbic acid metabolic process; IEA:Compara. GO:0015882; P:L-ascorbic acid transport; IDA:UniProtKB. GO:0006979; P:response to oxidative stress; IEA:Compara. GO:0070904; P:transepithelial L-ascorbic acid transport; IEA:Compara. |
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