UniProt Accession

 MSPD2_HUMAN; Q8NHP6; Q8N3H2; Q8NA83 

Genbank Protein ID

 AK093075; BC030641; AL834345 

Genbank Nucleotide ID

 BAC04043.1; AAH30641.1; CAD39011.1 

Protein Name

 Motile sperm domain-containing protein 2 

Protein Synonyms/Alias

  

Gene Name

 MOSPD2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
127	KTILDKKKLIAFWLE	ubiquitination	[1, 2, 3]
199	NAAFKIVKTWLGPEA	ubiquitination	[2]
211	PEAVSLLKFTSKNEV	ubiquitination	[1, 3]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

  

Sequence Annotation

 DOMAIN 82 239 CRAL-TRIO.
 DOMAIN 327 445 MSP.  

Keyword

 Alternative splicing; Complete proteome; Membrane; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 518 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005198; F:structural molecule activity; IEA:InterPro. 

Interpro

 IPR001251; CRAL-TRIO_dom.
 IPR011074; CRAL/TRIO_N_dom.
 IPR000535; Major_sperm.
 IPR008962; PapD-like. 

Pfam

 PF00650; CRAL_TRIO
 PF00635; Motile_Sperm 

SMART

 SM00516; SEC14 

PROSITE

 PS50191; CRAL_TRIO
 PS50202; MSP 

PRINTS