CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-028052
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 CG8677 
Protein Synonyms/Alias
  
Gene Name
 CG8677, Dmel_CG8677 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
289DQKSKKVKPLLISQAacetylation[1]
1599AGNLGRGKDISTIIEacetylation[1]
1609STIIEADKEKARRDDacetylation[1]
1839KLATQAEKKVKRLEYacetylation[1]
1875EGVPLSGKGSGKQPRacetylation[1]
1879LSGKGSGKQPRSQPLacetylation[1]
1887QPRSQPLKPTASSTLacetylation[1]
1897ASSTLTGKGKGKGKAacetylation[1]
1899STLTGKGKGKGKAKKacetylation[1]
1976IKRMLAEKNAEGAKIacetylation[1]
1993TPRLTPLKSGVTASEacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Metal-binding; Reference proteome; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2663 AA 
Protein Sequence
MAASSAAAAA PTNPIPLPTD SISEECKDDD ALTSTLHTCA NDPDFAVICA FLQKFGKDLG 60
LNLPNFKHLQ EWLTNNNDVP ELRDLHIKLL RKTRKTVHEK SWESALSKFC FGYSVQDAWE 120
IERFGYRNSS LKVKLRIFRE LLESQFERNA KFRAHILTLN ADTLRSEPIG RDRLGHAYWL 180
TQDAHCNLRI YQEHLDEEIW QVVATNRDEF VNLISRLRGN EVVLPSKDIG EADEDTSSSN 240
SCHPKPPPPE QKEEEDDEEV GDEPEKTVPN LKIKLRSPEQ EDQKSKKVKP LLISQAKLSS 300
SASPAPTKKR SIEDVDSSPT ASQEEQQKKH RPTLLDTKRI KKPSRYESTK DEIEEESGEE 360
DEEEEDEEDS ELDEGEEEED VDSAAADIEE DDDEEDTGEP IEDPTIVVQG QGSGLDCEAI 420
PYNLIGNFDY EDDLEIGEAI ADPMLHVIGQ GWGTDCLVGN GKNEASVEET STRTSEPKAT 480
FFFGEPGCLK LSPMKQTSKP EAKRGIFDSL SEEKTNGESE KCIVNTPPRN GSELTKTLGD 540
SEETASASAA TLEETNICQE ANVNKISDDQ IKKKESVPVA KRNIQDSTIS VIEKNEEISK 600
GRTESEAIEE GVRNRTEVSV LQNNSNESDN SSIQTQDQHK VPADLNNTKK PVTEKCVLES 660
GTVEDKLVIN HQQISTNALD TACDEKLSCE TESPVPNQHD SKMKSEQETA TSAKESVSES 720
SPTDGEDETA KSKCLIDPYA GKTNDKGIII NKIDKAEGVI KTLLQDDPPK DISKSETNTT 780
CLEINISPSA EHRISEKVQT IEPSTSQNLL FEDNGKSGEV DGKSRTSGAV EEISKTSTLL 840
NRKRRLNDSQ SALRNSTSES EVHEEEPQDD DPTLDDLDVG GKRIKMRPKT TNAESRRKVE 900
AQKTQIEETT SSSGEDDARI RRKCIAPHTK TKPTLEEIIE RKLKKSIEMD LPEKTTEKVM 960
EMPTQLMQKT REATPPIISL SPQKKTPITK PLKKNLLTQL RQEESEEETI PRKRTNSETL 1020
VPAIPASNVL CQPDERHRKR RSSEDANEAF SKESSPTEVP PSAVSEKLKR NNEQDIQEEV 1080
EDPLAMSVKD SLRSAKDQSP VPEGSARRSG RRGGPAVIHS ELPQPKRTRG GARDKMQPEV 1140
NAELKQESED DEKISTKIKS EAKDDPAPES PENRKKPEEK PIKEEPNEEP KPKVGRGRGP 1200
RKKREVDTTN IIETNDSETP VRQSRRIAQQ KIKEEAERRK QEEVALRTMK QELKKKKKAE 1260
KEADPTVLEP SGEESESEAS EAEEEARNKK KKKCPGKDGW SSDSEEQPES EEEEEEPPHY 1320
ETDPGSPLFR SDHEFSPESE LEDESQVVPM KRARTVRKEN ADDLEEEDAE EACQKCGKSD 1380
HPEWILLCDT PTCNKGYHCS CLSPVLFYIP EGDWHCPPCQ QEQLIAALER QLEQYDTLVA 1440
QKQQERILAE EQAERERQEL EAATLAAKDE NFKSEKEEDE DDRDDMAVGK AEKVKRRRGD 1500
GRINRRAAKR GTRRRRGNES DSSHRKSLGS GSRSGSGSDS SSDNSTSFSD SDDEPIYKLR 1560
KRRQINVSYR LNEYDDLINS ALKKEMDEVA GAGNLGRGKD ISTIIEADKE KARRDDLPTE 1620
DEVGNKEDGE KDKQKSKSSG SSPSSSEDEV PLKRSNKFKQ PPAKKKARKL TTLDVSSEED 1680
HGSDEDFKTS SYSDEDTSQS ASGDSDSSLE AYRRPGRGKK QRKAARRAAR ERRKDRKFVV 1740
EESDESEDED QKRRTTKSKK KKDDSDYTET ETEDDDDNEL SDNVDSADLC DDTTSESEDG 1800
AWNPSSKKKK TVAAKKSNSS GGIARKSPKL KKLATQAEKK VKRLEYSDDD ISESDLEEDD 1860
DDDEEDEEGV PLSGKGSGKQ PRSQPLKPTA SSTLTGKGKG KGKAKKKKQV SSEEEDGAAS 1920
DDRTRTRGRR YAYIEDDDDS SDGGIKPGVH RPDTPPEERQ KFIQRQEEIK RMLAEKNAEG 1980
AKIAATPRLT PLKSGVTASE KRTPGKAASG DSLSTVPLSV IRQAKVLDID YLQRKGETIG 2040
DLDDVDESEL DDAELPDDLP EDMEDAIARM VEEEEQFSAE VAARELPGAE EVLRTTPSKS 2100
KQTSRVMPES PAQNSAPSTS GLQEPHRKRL PMPTMHPPLL RHQFPISAGP SHSPASLVPP 2160
HAAQGMHPML QRHLSQTVPP PQAMHLLQNA LSAPLGQPLG CGNYGSGPNS AQHLPLVMSM 2220
PSAAAAAAHL MQSAVASATA RPVETASGNP ASDPKPRGRR KKVTPLRDQL QKQQTAAAVT 2280
AATSSTTPGS APSEKVKAQP LFKPHEDAAP SAPASQASVI TRMPSLLPPA HGRNHGPPSG 2340
LYPSSADLAR FYGQVANQQP IPAVPGSRSP SSTSGPPRHL LRPQMPPGLP PPHASLRPTY 2400
GPPPPLRGSG PPTSTPSTTT NSRPAYLHGA EHHGGPSGPP MGGVFSSGPP PARHATPHLN 2460
PYRAPPIYGN PNYSPRLGGA PGTGSMRPGA VDYVAGPRGY SPYGYYPPPP PLSTPSAHAA 2520
TSSVIVSAPH TLTPTNHSVP TLTHGKTPPQ QTPTQSSGPP PAAAPPPTIT SETSSHKPPL 2580
ASVITSKKLT TLEAYPIRKS PIAVVADVSG PAEPTRSPAP IAEEDSGSAH DTRAPSSATG 2640
TAVVGEFSGL VSYFSSQQDD YDT 2663 
Gene Ontology
 GO:0005705; C:polytene chromosome interband; IDA:FlyBase.
 GO:0031213; C:RSF complex; IPI:FlyBase.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0070868; P:heterochromatin organization involved in chromatin silencing; IMP:FlyBase. 
Interpro
 IPR018501; DDT_dom_superfamily.
 IPR019786; Zinc_finger_PHD-type_CS.
 IPR011011; Znf_FYVE_PHD.
 IPR001965; Znf_PHD.
 IPR019787; Znf_PHD-finger.
 IPR013083; Znf_RING/FYVE/PHD. 
Pfam
  
SMART
 SM00249; PHD 
PROSITE
 PS50827; DDT
 PS01359; ZF_PHD_1
 PS50016; ZF_PHD_2 
PRINTS