CPLM 1.0 - Compendium of Protein Lysine Modification
Tag
Content
CPLM ID
CPLM-038035
UniProt Accession
E9PU87_MOUSE
;
E9PU87
Genbank Protein ID
AC116503
;
AC122273
Genbank Nucleotide ID
Protein Name
Serine/threonine-protein kinase SIK3
Protein Synonyms/Alias
Gene Name
Sik3
Gene Synonyms/Alias
Created Date
July 27, 2013
Organism
Mus musculus (Mouse)
NCBI Taxa ID
10090
Lysine Modification
Position
Peptide
Type
References
337
IAECQQL
K
EERQSDP
acetylation
[1]
Reference
[1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [
PMID: 22826441
]
Functional Description
Sequence Annotation
Keyword
ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.
Sequence Source
UniProt (SWISSPROT/TrEMBL); GenBank; EMBL
Protein Length
1369 AA
Protein Sequence
MAAAAASGAG GVAVAGAGGA GPAGRLLPPP AAGPPAAPAA VPPAAVPARP TAPASRGSMA 60
ARIGYYEIDR TIGKGNFAVV KRATHLVTKA KVAIKIIDKS QLDEENLKKI FREVQIMKML 120
CHPHIIRLYQ VMETERMIYL VTEYASGGEI FDHLVAHGRM AEKEARRKFK QIVTAVYFCH 180
CRNIVHRDLK AENLLLDANL NIKIADFGFS NLFTPGQLLK TWCGSPPYAA PELFEGKEYD 240
GPKVDIWSLG VVLYVLVCGA LPFDGSTLQN LRARVLSGKF RIPFFMSTEC EHLIRHMLVL 300
DPNKRLSMEQ ICRHKWMKLG DADPNFDRLI AECQQLKEER QSDPLNDDVL LAMEDMGLDK 360
ERTLQSLRSD AYDHYSAIYS LLCDRHKKHK TLRPGALPSM PQAMTFQAPV NLQAEQTGTA 420
MNLSVPQVQL INPENQIIEP DGAVNLDSDE GEEPSPEALV RYLSMRRHTV GVADPRTEVM 480
EDLQKLLPGF PGVNPQGPFL QVAPNMNFTH NLLPMQSLQP TGQLEYKEQS LLQPPTLQLL 540
NGMGPLGRRA SDGGANIQLH AQQLLKRPRG PSPLVTMTPA VPAVTPVDEE SSDGEPDQEA 600
VQRYLANRSK RHTLAMTSPT AEIPPDLQRQ LGQQSFRSRV WPPHLVPDQH RSTYKDSNTL 660
HLPTERFSPV RRFSDGAASI QAFKAHLEKM GNSSSIKQLQ QECEQLQKMY GGQVDERTLE 720
KTQQQHMLYQ QEQHHQILQQ QIQDSICPPQ PSPPLQVACE NQPALLTHQL QRLRIQPSSP 780
PPNHPSNHLF RQPSNSPPPV SSAMITSHGA TSPSQFQGLP SHGAIFQQQP ENCSPPPSVA 840
LTCLGLQQAS QSQPVTIQLQ EPVDMLSNMA GTAAGSAGRS IPISPSASQI QIQHRASLMA 900
PFSYGHRPLS KQLSADSAEA HSLNMNRFSP ANYDQAHLHP HLFSDQSRGS PSSYSPSTGV 960
GFPPTQALKV PPLDQFPTFP PSAQQQPPHY TTSALQQALL SPTPPDYPRH QQVPHILQGL 1020
LSPRHSLTGH SDIRLPPAEF AQLIKRQQQH RQQQQQQQQQ QEYHELFRHM NQGDAVSLAP 1080
SLGGQNMTEQ QALSYQNADS YHRHHTSPQH ILQIRAQDCI SQGPSPTPTH GYAHQPPLMH 1140
SESMEEDCLC EGLKEGFPDK SSSTLTKGCH NSPLLLCTSG PGDPEPLLGT VSQARELGIH 1200
PYGHQPTATT FSRNKVPSRE SVLGNCLERS SPGQAMELPD HNGLGYPVRP LVSEHLRSRT 1260
LQRHHTIQNS DDAYVQLDTL PGMSLVAGKA LSSARMSDAV LSQSSLMGSQ QFQDEEDEEC 1320
GVSLGHEHPG LGDGSQHLNS SRYPATCVTD IMLSHKHPEV SFSMEQAGV 1369
Gene Ontology
GO:0005524
; F:ATP binding; IEA:UniProtKB-KW.
GO:0000287
; F:magnesium ion binding; IEA:Compara.
GO:0004674
; F:protein serine/threonine kinase activity; IEA:Compara.
Interpro
IPR011009
; Kinase-like_dom.
IPR000719
; Prot_kinase_cat_dom.
IPR017441
; Protein_kinase_ATP_BS.
IPR002290
; Ser/Thr_dual-sp_kinase_dom.
IPR008271
; Ser/Thr_kinase_AS.
IPR015940
; UBA/transl_elong_EF1B_N_euk.
Pfam
PF00069
; Pkinase
SMART
SM00220
; S_TKc
PROSITE
PS00107
; PROTEIN_KINASE_ATP
PS50011
; PROTEIN_KINASE_DOM
PS00108
; PROTEIN_KINASE_ST
PS50030
; UBA
PRINTS