CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-042795
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Serine/threonine-protein phosphatase 
Protein Synonyms/Alias
  
Gene Name
 PPP5C 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
25PPADGALKRAEELKTubiquitination[1]
31LKRAEELKTQANDYFacetylation[2]
31LKRAEELKTQANDYFubiquitination[1, 3]
39TQANDYFKAKDYENAubiquitination[1, 3]
41ANDYFKAKDYENAIKubiquitination[1]
48KDYENAIKFYSQAIEubiquitination[1, 3]
92TRAIELDKKYIKGYYacetylation[4]
93RAIELDKKYIKGYYRubiquitination[1]
96ELDKKYIKGYYRRAAubiquitination[1, 4]
110ASNMALGKFRAALRDubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
  
Sequence Annotation
 ACT_SITE 303 303 Proton donor (By similarity).
 METAL 241 241 Iron (By similarity).
 METAL 243 243 Iron (By similarity).
 METAL 270 270 Iron (By similarity).  
Keyword
 Complete proteome; Hydrolase; Iron; Metal-binding; Reference proteome; Repeat; TPR repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 485 AA 
Protein Sequence
XMAEGERTEC AEPPRDEPPA DGALKRAEEL KTQANDYFKA KDYENAIKFY SQAIELNPSN 60
AIYYGNRSLA YLRTECYGYA LGDATRAIEL DKKYIKGYYR RAASNMALGK FRAALRDYET 120
VVKVKPHDKD AKMKYQECNK IVKQKAFERA IAGDEHKRSV VDSLDIESMT IEDEYSGPKL 180
EDGKVTISFM KELMQWYKDQ KKLHRKCAYQ ILVQVKEVLS KLSTLVETTL KETEKITVCG 240
DTHGQFYDLL NIFELNGLPS ETNPYIFNGD FVDRGSFSVE VILTLFGFKL LYPDHFHLLR 300
GNHETDNMNQ IYGFEGEVKA KYTAQMYELF SEVFEWLPLA QCINGKVLIM HGGLFSEDGV 360
TLDDIRKIER NRQPPDSGPM CDLLWSDPQP QNGRSISKRG VSCQFGPDVT KAFLEENNLD 420
YIIRSHEVKA EGYEVAHGGR CVTVFSAPNY CDQMGNKASY IHLQGSDLRP QFHQFTAVGR 480
PSSGS 485 
Gene Ontology
 GO:0005794; C:Golgi apparatus; IDA:HPA.
 GO:0005634; C:nucleus; IEA:InterPro.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0004721; F:phosphoprotein phosphatase activity; IEA:EC.
 GO:0006470; P:protein dephosphorylation; IEA:InterPro. 
Interpro
 IPR004843; Metallo_PEstase_dom.
 IPR013235; PPP_dom.
 IPR006186; Ser/Thr-sp_prot-phosphatase.
 IPR011236; Ser/Thr_PPase_5.
 IPR001440; TPR-1.
 IPR013026; TPR-contain_dom.
 IPR011990; TPR-like_helical.
 IPR019734; TPR_repeat. 
Pfam
 PF00149; Metallophos
 PF08321; PPP5
 PF00515; TPR_1 
SMART
 SM00156; PP2Ac
 SM00028; TPR 
PROSITE
 PS00125; SER_THR_PHOSPHATASE
 PS50005; TPR
 PS50293; TPR_REGION 
PRINTS
 PR00114; STPHPHTASE.