| Tag | Content |
|---|
| CPLM ID | CPLM-014774 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Mannose-6-phosphate isomerase |
Protein Synonyms/Alias | Phosphohexomutase; Phosphomannose isomerase; PMI |
Gene Name | Mpi |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 93 | VKDTFNGKLPFLFKV | acetylation | [1] | | 180 | EDATAQLKKSMNEGS | acetylation | [1] | | 412 | LLKLTVPKNLLIFRA | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions (By similarity). |
Sequence Annotation | ACT_SITE 295 295 By similarity.
METAL 110 110 Zinc (By similarity).
METAL 112 112 Zinc (By similarity).
METAL 137 137 Zinc (By similarity).
METAL 276 276 Zinc (By similarity).
MOD_RES 2 2 N-acetylalanine (By similarity). |
Keyword | Acetylation; Complete proteome; Cytoplasm; Isomerase; Metal-binding; Reference proteome; Zinc. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 423 AA |
Protein Sequence | MANPRVFPLS CVVQQYAWGK VGSKSEVACL LACSDPLTQI SEDKPYAELW MGAHPRGDAK 60
ILDNRISQKT LGQWIAENQN SLGQKVKDTF NGKLPFLFKV LSVETALSIQ AHPNKELAEK 120
LHLQAPEHYP DANHKPEMAI ALTPFQGLCG FRPVEEIVTF LKKVPEFQSL IGEDATAQLK 180
KSMNEGSGAM ASALKNCFSH LMKSEKKVVV EQLNLLVKRI SQQISNGNSM DDICGELLLQ 240
LHQQYPGDIG CFAIYLLNLI TLKPGEAMFL EANVPHAYLK GDCVECMACS DNTVRAGLTP 300
KFIDVSTLCE MLDYTPSPSK DRLFAPTLSQ DDPYLSIYDP PVPDFTVMKI EVPGSVTEYK 360
VLTLDSASIL LLVQGTVTAI IPSVQGEIPL SRGGVLFIGA NETVLLKLTV PKNLLIFRAC 420
CLL 423 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0004476; F:mannose-6-phosphate isomerase activity; IEA:EC. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0005975; P:carbohydrate metabolic process; IEA:InterPro. GO:0009298; P:GDP-mannose biosynthetic process; IEA:UniProtKB-UniPathway. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |