UniProt Accession

 PPR3B_HUMAN; Q86XI6; B3KTV3; Q9H812 

Genbank Protein ID

 AK024067; AK096119; CH471157; BC043388 

Genbank Nucleotide ID

 BAB14811.1; BAG53215.1; EAW65572.1; AAH43388.1 

Protein Name

 Protein phosphatase 1 regulatory subunit 3B 

Protein Synonyms/Alias

 Hepatic glycogen-targeting protein phosphatase 1 regulatory subunit GL; Protein phosphatase 1 regulatory subunit 4; PP1 subunit R4; Protein phosphatase 1 subunit GL; PTG 

Gene Name

 PPP1R3B 

Gene Synonyms/Alias

 PPP1R4 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
58	APAVQEKKVKKRVSF	ubiquitination	[1]
141	CLENCVLKDKAIAGT	ubiquitination	[1]
143	ENCVLKDKAIAGTVK	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Acts as a glycogen-targeting subunit for phosphatase PP1. Facilitates interaction of the PP1 with enzymes of the glycogen metabolism and regulates its activity. Suppresses the rate at which PP1 dephosphorylates (inactivates) glycogen phosphorylase and enhances the rate at which it activates glycogen synthase and therefore limits glycogen breakdown. Its activity is inhibited by PYGL, resulting in inhibition of the glycogen synthase and glycogen phosphorylase phosphatase activities of PP1. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in hepatocytes (By similarity). 

Sequence Annotation

 DOMAIN 125 233 CBM21.
 MOTIF 62 65 PP1-binding motif.  

Keyword

 3D-structure; Carbohydrate metabolism; Complete proteome; Glycogen metabolism; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 285 AA 

Protein Sequence

Gene Ontology

 GO:0042587; C:glycogen granule; IEA:Compara.
 GO:0043231; C:intracellular membrane-bounded organelle; IEA:Compara.
 GO:0000164; C:protein phosphatase type 1 complex; IEA:Compara.
 GO:0019888; F:protein phosphatase regulator activity; IEA:Compara.
 GO:0005977; P:glycogen metabolic process; IEA:UniProtKB-KW.
 GO:0005979; P:regulation of glycogen biosynthetic process; IEA:Compara.
 GO:0005981; P:regulation of glycogen catabolic process; IEA:Compara. 

Interpro

 IPR005036; CBM_21.
 IPR017434; Pase-1_Glycogen_target-su_met. 

Pfam

 PF03370; CBM_21 

SMART

  

PROSITE

 PS51159; CBM21 

PRINTS