UniProt Accession

 PGAM2_RAT; P16290 

Genbank Protein ID

 M31835; Z17319 

Genbank Nucleotide ID

 AAA41835.1; CAA78967.1 

Protein Name

 Phosphoglycerate mutase 2 

Protein Synonyms/Alias

 BPG-dependent PGAM 2; Muscle-specific phosphoglycerate mutase; Phosphoglycerate mutase isozyme M; PGAM-M 

Gene Name

 Pgam2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
106	NKAETAAKHGEEQVK	acetylation	[1]
113	KHGEEQVKIWRRSFD	acetylation	[1]
129	PPPPMDEKHNYYASI	acetylation	[1]
138	NYYASISKDRRYAGL	acetylation	[1]
146	DRRYAGLKPEELPTC	acetylation	[1]
157	LPTCESLKDTIARAL	acetylation	[1]
174	WNEEIAPKIKAGKRV	acetylation	[1]
174	WNEEIAPKIKAGKRV	methylation	[2]
225	YELNQELKPTKPMRF	acetylation	[1]
228	NQELKPTKPMRFLGD	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Post-translational modifications in the rat lumbar spinal cord in experimental autoimmune encephalomyelitis.
 Grant JE, Hu J, Liu T, Jain MR, Elkabes S, Li H.
 J Proteome Res. 2007 Jul;6(7):2786-91. [PMID: 17567059] 

Functional Description

 Interconversion of 3- and 2-phosphoglycerate with 2,3- bisphosphoglycerate as the primer of the reaction. Can also catalyze the reaction of EC 5.4.2.4 (synthase) and EC 3.1.3.13 (phosphatase), but with a reduced activity. 

Sequence Annotation

 ACT_SITE 11 11 Tele-phosphohistidine intermediate.
 ACT_SITE 186 186
 MOD_RES 92 92 Phosphotyrosine (By similarity).
 CROSSLNK 179 179 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 195 195 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 Complete proteome; Glycolysis; Hydrolase; Isomerase; Isopeptide bond; Phosphoprotein; Reference proteome; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 253 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:RGD.
 GO:0005634; C:nucleus; IDA:RGD.
 GO:0046538; F:2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity; IMP:RGD.
 GO:0004083; F:bisphosphoglycerate 2-phosphatase activity; IEA:EC.
 GO:0004082; F:bisphosphoglycerate mutase activity; IEA:EC.
 GO:0048037; F:cofactor binding; IMP:RGD.
 GO:0006094; P:gluconeogenesis; IDA:RGD.
 GO:0006096; P:glycolysis; IEA:UniProtKB-KW.
 GO:0046689; P:response to mercury ion; IMP:RGD.
 GO:0007283; P:spermatogenesis; IEP:RGD.
 GO:0006941; P:striated muscle contraction; IEA:Compara. 

Interpro

 IPR013078; His_Pase_superF_clade-1.
 IPR001345; PG/BPGM_mutase_AS.
 IPR005952; Phosphogly_mut1. 

Pfam

 PF00300; His_Phos_1 

SMART

 SM00855; PGAM 

PROSITE

 PS00175; PG_MUTASE 

PRINTS