CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021892
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Acetoacetyl-CoA synthetase 
Protein Synonyms/Alias
  
Gene Name
 Aacs 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
391WLSVLEEKDMKPMETacetylation[1]
601TFQPDLVKHIRDAIRacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Activates acetoacetate to acetoacetyl-CoA. May be involved in utilizing ketone body for the fatty acid-synthesis during adipose tissue development. 
Sequence Annotation
 MOD_RES 524 524 Phosphotyrosine (By similarity).  
Keyword
 ATP-binding; Complete proteome; Cytoplasm; Direct protein sequencing; Fatty acid metabolism; Ligase; Lipid metabolism; Nucleotide-binding; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 672 AA 
Protein Sequence
MSKLARLERE EIMECQVMWE PDSKKDTQMD RFRAAVGTAC GLALGNYDDL YHWSVRSYSD 60
FWAEFWKFSG IVCSRMYDEV VDTSKGIADV PEWFRGSRLN YAENLLRHKE NDRVALYVAR 120
EGREEIAKVT FEELRQQVAL FAAAMRKMGV KKGDRVVGYL PNSAHAVEAM LAAASIGAIW 180
SSTSPDFGVN GVLDRFSQIQ PKLIFSVEAV VYNGKEHGHL EKLQRVVKGL PDLQRVVLIP 240
YVLPREKIDI SKIPNSMFLD DFLASGTGAQ APQLEFEQLP FSHPLFIMFS SGTTGAPKCM 300
VHSAGGTLIQ HLKEHVLHGN MTSSDILLYY TTVGWMMWNW MVSALATGAS LVLYDGSPLV 360
PTPNVLWDLV DRIGITILGT GAKWLSVLEE KDMKPMETHN LHTLHTILST GSPLKAQSYE 420
YVYRCIKSTV LLGSISGGTD IISCFMGQNS SIPVYKGEIQ ARNLGMAVEA WDEEGKTVWG 480
ASGELVCTKP IPCQPTHFWN DENGSKYRKA YFSKYPGVWA HGDYCRINPK TGGIVMLGRS 540
DGTLNPNGVR FGSSEIYNIV EAFDEVEDSL CVPQYNRDGE ERVVLFLKMA SGHTFQPDLV 600
KHIRDAIRLG LSARHVPSLI LETQGIPYTI NGKKVEVAVK QVIAGKTVEH RGAFSNPESL 660
DLYRDIPELQ DF 672 
Gene Ontology
 GO:0005829; C:cytosol; IDA:RGD.
 GO:0030729; F:acetoacetate-CoA ligase activity; IDA:RGD.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0047760; F:butyrate-CoA ligase activity; IDA:RGD.
 GO:0060612; P:adipose tissue development; IEP:RGD.
 GO:0071397; P:cellular response to cholesterol; IEP:RGD.
 GO:0071333; P:cellular response to glucose stimulus; IMP:RGD.
 GO:0071394; P:cellular response to testosterone stimulus; IEP:RGD.
 GO:0006631; P:fatty acid metabolic process; IEA:UniProtKB-KW.
 GO:0001889; P:liver development; IDA:RGD.
 GO:0032024; P:positive regulation of insulin secretion; IMP:RGD.
 GO:0042493; P:response to drug; IDA:RGD.
 GO:0045471; P:response to ethanol; IDA:RGD.
 GO:0007584; P:response to nutrient; IDA:RGD.
 GO:0034201; P:response to oleic acid; IDA:RGD.
 GO:0014074; P:response to purine-containing compound; IEP:RGD.
 GO:0042594; P:response to starvation; IEP:RGD.
 GO:0050872; P:white fat cell differentiation; IEP:RGD. 
Interpro
 IPR005914; Acac_CoA_synth.
 IPR020845; AMP-binding_CS.
 IPR000873; AMP-dep_Synth/Lig. 
Pfam
 PF00501; AMP-binding 
SMART
  
PROSITE
 PS00455; AMP_BINDING 
PRINTS