UniProt Accession

 SERB_MOUSE; Q99LS3; Q3TI16; Q5XHW3 

Genbank Protein ID

 AK088865; AK168048; BC002251 

Genbank Nucleotide ID

 BAC40622.1; BAE40030.1; AAH02251.1 

Protein Name

 Phosphoserine phosphatase 

Protein Synonyms/Alias

 PSP; PSPase; O-phosphoserine phosphohydrolase 

Gene Name

 Psph 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
122	IVEHVAAKLNIPTTN	acetylation	[1]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 

Functional Description

 Catalyzes the last step in the biosynthesis of serine from carbohydrates. The reaction mechanism proceeds via the formation of a phosphoryl-enzyme intermediates (By similarity). 

Sequence Annotation

 REGION 109 110 Substrate binding (By similarity).
 ACT_SITE 20 20 Nucleophile (By similarity).
 ACT_SITE 22 22 Proton donor (By similarity).
 METAL 20 20 Magnesium (By similarity).
 METAL 22 22 Magnesium; via carbonyl oxygen (By
 METAL 179 179 Magnesium (By similarity).
 BINDING 29 29 Substrate (By similarity).
 BINDING 65 65 Substrate (By similarity).
 BINDING 158 158 Substrate (By similarity).
 MOD_RES 1 1 N-acetylmethionine (By similarity).  

Keyword

 Acetylation; Amino-acid biosynthesis; Complete proteome; Hydrolase; Magnesium; Metal-binding; Phosphoprotein; Reference proteome; Serine biosynthesis. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 225 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IBA:RefGenome.
 GO:0043005; C:neuron projection; IEA:Compara.
 GO:0005509; F:calcium ion binding; ISS:UniProtKB.
 GO:0000287; F:magnesium ion binding; ISS:UniProtKB.
 GO:0004647; F:phosphoserine phosphatase activity; ISS:UniProtKB.
 GO:0006564; P:L-serine biosynthetic process; IBA:RefGenome.
 GO:0009612; P:response to mechanical stimulus; IEA:Compara.
 GO:0031667; P:response to nutrient levels; IEA:Compara.
 GO:0033574; P:response to testosterone stimulus; IEA:Compara. 

Interpro

 IPR023214; HAD-like_dom.
 IPR006383; HAD-SF_hydro_IB_PSP-like.
 IPR023190; Pser_Pase_dom_2.
 IPR004469; SerB. 

Pfam

  

SMART

  

PROSITE

  

PRINTS