UniProt Accession

 H0YJG9_HUMAN; H0YJG9 

Genbank Protein ID

 AL135999 

Genbank Nucleotide ID

  

Protein Name

 Dehydrogenase/reductase SDR family member 2 

Protein Synonyms/Alias

  

Gene Name

 DHRS2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
124	IIKTDFSKVFHGNES	acetylation	[1]
124	IIKTDFSKVFHGNES	ubiquitination	[2]
134	HGNESLWKNFKEHHQ	acetylation	[3]
134	HGNESLWKNFKEHHQ	ubiquitination	[2]

Reference

 [1] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 161 AA 

Protein Sequence

Gene Ontology

 GO:0016491; F:oxidoreductase activity; IEA:InterPro.
 GO:0055114; P:oxidation-reduction process; IEA:GOC. 

Interpro

 IPR002198; DH_sc/Rdtase_SDR.
 IPR027052; DHRS2/4.
 IPR002347; Glc/ribitol_DH.
 IPR016040; NAD(P)-bd_dom.
 IPR020904; Sc_DH/Rdtase_CS. 

Pfam

  

SMART

  

PROSITE

 PS00061; ADH_SHORT 

PRINTS

 PR00081; GDHRDH.
 PR00080; SDRFAMILY.