CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037281
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial 
Protein Synonyms/Alias
  
Gene Name
 SDHA 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
92FNTACVTKLFPTRSHubiquitination[1]
287ERYAPVAKDLASRDVubiquitination[1]
469ELRLSMQKSMQNHAAubiquitination[2]
490VLQEGCGKISKLYGDubiquitination[3]
493EGCGKISKLYGDLKHacetylation[4]
493EGCGKISKLYGDLKHubiquitination[5]
499SKLYGDLKHLKTFDRacetylation[4, 6, 7]
499SKLYGDLKHLKTFDRubiquitination[3]
502YGDLKHLKTFDRGMVubiquitination[3]
560IDEYDYSKPIQGQQKubiquitination[1]
Reference
 [1] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [5] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [6] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [7] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 616 AA 
Protein Sequence
MSGVRGLSRL LSARRLALAK AWPTVLQTGT RGFHFTVDGN KRASAKVSDS ISAQYPVVDH 60
EFDAVVVGAG GAGLRAAFGL SEAGFNTACV TKLFPTRSHT VAAQLENYGM PFSRTEDGKI 120
YQRAFGGQSL KFGKGGQAHR CCCVADRTGH SLLHTLYGRS LRYDTSYFVE YFALDLLMEN 180
GECRGVIALC IEDGSIHRIR AKNTVVATGG YGRTYFSCTS AHTSTGDGTA MITRAGLPCQ 240
DLEFVQFHPT GIYGAGCLIT EGCRGEGGIL INSQGERFME RYAPVAKDLA SRDVVSRSMT 300
LEIREGRGCG PEKDHVYLQL HHLPPEQLAT RLPGISETAM IFAGVDVTKE PIPVLPTVHY 360
NMGGIPTNYK GQVLRHVNGQ DQIVPGLYAC GEAACASVHG ANRLGANSLL DLVVFGRACA 420
LSIEESCRPG DKVPPIKPNA GEESVMNLDK LRFADGSIRT SELRLSMQKS MQNHAAVFRV 480
GSVLQEGCGK ISKLYGDLKH LKTFDRGMVW NTDLVETLEL QNLMLCALQT IYGAEARKES 540
RGAHAREDYK VRIDEYDYSK PIQGQQKKPF EEHWRKHTLS YVDVGTGKVT LEYRPVIDKT 600
LNEADCATVP PAIRSY 616 
Gene Ontology
 GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
 GO:0016627; F:oxidoreductase activity, acting on the CH-CH group of donors; IEA:InterPro.
 GO:0022900; P:electron transport chain; IEA:InterPro.
 GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro. 
Interpro
 IPR003953; FAD_bind_dom.
 IPR015939; Fum_Rdtase/Succ_DH_flav-like_C.
 IPR027477; Succ_DH/fumarate_Rdtase_cat.
 IPR011281; Succ_DH_flav_su_fwd.
 IPR014006; Succ_Dhase_FrdA_Gneg. 
Pfam
 PF00890; FAD_binding_2
 PF02910; Succ_DH_flav_C 
SMART
  
PROSITE
  
PRINTS