| Tag | Content |
|---|
| CPLM ID | CPLM-002207 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Fumarate hydratase class II |
Protein Synonyms/Alias | Fumarase C; Iron-independent fumarase |
Gene Name | fumC |
Gene Synonyms/Alias | b1611; JW1603 |
Created Date | July 27, 2013 |
Organism | Escherichia coli (strain K12) |
NCBI Taxa ID | 83333 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 8 | MNTVRSEKDSMGAID | acetylation | [1] | | 20 | AIDVPADKLWGAQTQ | acetylation | [1] | | 39 | HFRISTEKMPTSLIH | acetylation | [1] | | 69 | LGLLSEEKASAIRQA | acetylation | [1] | | 158 | AALLALRKQLIPQLK | acetylation | [1] | | 165 | KQLIPQLKTLTQTLN | acetylation | [1] | | 183 | RAFADIVKIGRTHLQ | acetylation | [1] |
|
Reference | [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli. Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C. Mol Cell. 2013 Jul 25;51(2):265-72. [ PMID: 23830618] |
Functional Description | Catalyzes the reversible addition of water to fumarate to give L-malate. |
Sequence Annotation | REGION 98 100 Substrate binding.
REGION 129 132 B site.
REGION 139 141 Substrate binding.
REGION 187 188 Substrate binding (By similarity).
REGION 324 326 Substrate binding (By similarity).
ACT_SITE 188 188 Proton donor/acceptor (By similarity).
ACT_SITE 318 318 By similarity.
BINDING 319 319 Substrate (By similarity). |
Keyword | 3D-structure; Allosteric enzyme; Complete proteome; Cytoplasm; Direct protein sequencing; Lyase; Reference proteome; Tricarboxylic acid cycle. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 467 AA |
Protein Sequence | MNTVRSEKDS MGAIDVPADK LWGAQTQRSL EHFRISTEKM PTSLIHALAL TKRAAAKVNE 60
DLGLLSEEKA SAIRQAADEV LAGQHDDEFP LAIWQTGSGT QSNMNMNEVL ANRASELLGG 120
VRGMERKVHP NDDVNKSQSS NDVFPTAMHV AALLALRKQL IPQLKTLTQT LNEKSRAFAD 180
IVKIGRTHLQ DATPLTLGQE ISGWVAMLEH NLKHIEYSLP HVAELALGGT AVGTGLNTHP 240
EYARRVADEL AVITCAPFVT APNKFEALAT CDALVQAHGA LKGLAASLMK IANDVRWLAS 300
GPRCGIGEIS IPENEPGSSI MPGKVNPTQC EALTMLCCQV MGNDVAINMG GASGNFELNV 360
FRPMVIHNFL QSVRLLADGM ESFNKHCAVG IEPNRERINQ LLNESLMLVT ALNTHIGYDK 420
AAEIAKKAHK EGLTLKAAAL ALGYLSEAEF DSWVRPEQMV GSMKAGR 467 |
Gene Ontology | GO:0045239; C:tricarboxylic acid cycle enzyme complex; IEA:InterPro. GO:0004333; F:fumarate hydratase activity; IDA:EcoCyc. GO:0006106; P:fumarate metabolic process; IEA:InterPro. GO:0006979; P:response to oxidative stress; IEP:EcoCyc. GO:0006099; P:tricarboxylic acid cycle; IEA:HAMAP. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |