CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-041793
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Thioredoxin reductase 3 
Protein Synonyms/Alias
  
Gene Name
 Txnrd3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
351FDQEMAEKVGSYLEQacetylation[1]
351FDQEMAEKVGSYLEQsuccinylation[1]
Reference
 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; FAD; Flavoprotein; Oxidoreductase; Redox-active center; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 615 AA 
Protein Sequence
MSSPPGRRAR LASPGTSRPS SEAREELRRR LRDLIEGNRV MIFSKSYCPH STRVKELFSS 60
LGVVYNILEL DQVDDGASVQ EVLTEISNQK TVPNIFVNKV HVGGCDRTFQ AHQNGLLQKL 120
LQDDSAHDYD LIIIGGGSGG LSCAKEAANL GKKVMVLDFV VPSPQGTTWG LGGTCVNVGC 180
IPKKLMHQAA LLGHALQDAK KYGWEYNQQV KHNWEAMTEA IQSHIGSLNW GYRVTLREKG 240
VTYVNSFGEF VDLHKIKATN KKGQETFYTA SKFVIATGER PRYLGIQGDK EYCITSDDLF 300
SLPYCPGCTL VVGASYVGLE CAGFLAGLGL DVTVMVRSVL LRGFDQEMAE KVGSYLEQQG 360
VKFQRKFTPI LVQQLEKGLP GKLKVVAKST EGPETVEGIY NTVLLAIGRD SCTRKIGLEK 420
IGVKINEKNG KIPVNDVEQT NVPHVYAIGD ILDGKPELTP VAIQAGKLLA RRLFGVSLEK 480
CDYINIPTTV FTPLEYGCCG LSEEKAIEMY KKENLEVYHT LFWPLEWTVA GRDNNTCYAK 540
IICNKFDNER VVGFHLLGPN AGEITQGFAA AMKCGLTKQL LDDTIGIHPT CGEVFTTLEI 600
TKSSGLDITQ KGCCG 615 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:InterPro.
 GO:0009055; F:electron carrier activity; IEA:InterPro.
 GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
 GO:0050661; F:NADP binding; IEA:InterPro.
 GO:0015035; F:protein disulfide oxidoreductase activity; IEA:InterPro.
 GO:0004791; F:thioredoxin-disulfide reductase activity; IDA:MGI.
 GO:0045454; P:cell redox homeostasis; IEA:InterPro.
 GO:0006749; P:glutathione metabolic process; IDA:MGI. 
Interpro
 IPR016156; FAD/NAD-linked_Rdtase_dimer.
 IPR013027; FAD_pyr_nucl-diS_OxRdtase.
 IPR002109; Glutaredoxin.
 IPR011899; Glutaredoxin_euk/vir.
 IPR004099; Pyr_nucl-diS_OxRdtase_dimer.
 IPR023753; Pyr_nucl-diS_OxRdtase_FAD/NAD.
 IPR012999; Pyr_OxRdtase_I_AS.
 IPR001327; Pyr_OxRdtase_NAD-bd_dom.
 IPR012336; Thioredoxin-like_fold.
 IPR006338; Thioredoxin/glutathione_Rdtase. 
Pfam
 PF00462; Glutaredoxin
 PF00070; Pyr_redox
 PF07992; Pyr_redox_2
 PF02852; Pyr_redox_dim 
SMART
  
PROSITE
 PS51354; GLUTAREDOXIN_2
 PS00076; PYRIDINE_REDOX_1 
PRINTS
 PR00368; FADPNR.