| Tag | Content |
|---|
| CPLM ID | CPLM-018136 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | NADPH oxidase organizer 1 |
Protein Synonyms/Alias | Nox organizer 1; Sorting nexin-28 |
Gene Name | Noxo1 |
Gene Synonyms/Alias | Snx28 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 53 | RQLQKTLKKTFPVEA | acetylation | [1] | | 54 | QLQKTLKKTFPVEAG | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Constitutively potentiates the superoxide-generating activity of NOX1 and NOX3 and is required for the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity. Isoform 3 is more potent than isoform 1 in activating NOX3. Together with NOXA1, may also substitute to NCF1/p47phox and NCF2/p67phox in supporting the phagocyte NOX2/gp91phox superoxide-generating activity. |
Sequence Annotation | DOMAIN 1 126 PX.
DOMAIN 157 219 SH3 1.
DOMAIN 231 290 SH3 2.
REGION 315 324 Proline-rich region; mediates mutually |
Keyword | Alternative splicing; Cell membrane; Complete proteome; Lipid-binding; Membrane; Reference proteome; Repeat; SH3 domain. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 349 AA |
Protein Sequence | MASPRHPVSA HAVALVQMDR LQTFAFSVCW SDNSDTFVRR SWDEFRQLQK TLKKTFPVEA 60
GLLRRSEQVL PKLPDAPLLT RRGHTGRGLV RLRLLDTYVQ ALLATSEHIL RSSALHGFFV 120
PKPLDLEPML PPGSLVILPT PEEPLSQPRG SLDIHSLEAQ SIPCVQPFHT LDIRDRPFHT 180
KAQEILDILL RHPSGWWLVE NKDQQVAWFP APYLEEVATC QGQESGLALQ GSGRQFCTTQ 240
AYEGSRSDEL SVPSGARVHV LETSDRGWWL CRYNGRTGLL PAMSLQPEGL GSLLGRPGFP 300
DSAGADKVAE DRTIPPVVPT RPCMSAIQSR CCSITRRALG QEQGTRVPR 349 |
Gene Ontology | GO:0043020; C:NADPH oxidase complex; IEA:Compara. GO:0035091; F:phosphatidylinositol binding; IEA:InterPro. GO:0016176; F:superoxide-generating NADPH oxidase activator activity; IDA:MGI. GO:0007154; P:cell communication; IEA:InterPro. GO:0022617; P:extracellular matrix disassembly; ISS:UniProtKB. GO:0006801; P:superoxide metabolic process; IDA:MGI. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |