CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019760
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Kinesin-like protein KIF2C 
Protein Synonyms/Alias
 Kinesin-like protein 6; Mitotic centromere-associated kinesin; MCAK 
Gene Name
 KIF2C 
Gene Synonyms/Alias
 KNSL6 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
311MGGDLSGKAQNASKGubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis. 
Sequence Annotation
 DOMAIN 255 518 Kinesin-motor.
 NP_BIND 348 355 ATP.
 REGION 1 254 Globular (Potential).
 REGION 207 238 Negative regulator of microtubule-binding
 MOTIF 98 101 Microtubule tip localization signal.
 MOTIF 415 418 Nuclear localization signal (Potential).
 BINDING 264 264 ATP (By similarity).
 MOD_RES 22 22 Phosphoserine.
 MOD_RES 95 95 Phosphoserine; by AURKB.
 MOD_RES 109 109 Phosphoserine (By similarity).
 MOD_RES 111 111 Phosphoserine (By similarity).
 MOD_RES 115 115 Phosphoserine (By similarity).
 MOD_RES 166 166 Phosphoserine.
 MOD_RES 192 192 Phosphoserine (By similarity).
 MOD_RES 621 621 Phosphoserine.
 MOD_RES 633 633 Phosphoserine.  
Keyword
 3D-structure; Alternative splicing; ATP-binding; Cell cycle; Cell division; Centromere; Chromosome; Chromosome partition; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Kinetochore; Microtubule; Mitosis; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 725 AA 
Protein Sequence
MIDFDDVAAI NPELLQLLPL HPKDNLPLQE NVTIQKQKRR SVNSKIPAPK ESLRSRSTRM 60
STVSELRITA QENDMEVELP AAANSRKQFS VPPAPTRPSC PAVAEIPLRM VSEEMEEQVH 120
SIRGSSSANP VNSVRRKSCL VKEVEKMKNK REEKKAQNSE MRMKRAQEYD SSFPNWEFAR 180
MIKEFRATLE CHPLTMTDPI EEHRICVCVR KRPLNKQELA KKEIDVISIP SKCLLLVHEP 240
KLKVDLTKYL ENQAFCFDFA FDETASNEVV YRFTARPLVQ TIFEGGKATC FAYGQTGSGK 300
THTMGGDLSG KAQNASKGIY AMASRDVFLL KNQPCYRKLG LEVYVTFFEI YNGKLFDLLN 360
KKAKLRVLED GKQQVQVVGL QEHLVNSADD VIKMIDMGSA CRTSGQTFAN SNSSRSHACF 420
QIILRAKGRM HGKFSLVDLA GNERGADTSS ADRQTRMEGA EINKSLLALK ECIRALGQNK 480
AHTPFRESKL TQVLRDSFIG ENSRTCMIAT ISPGISSCEY TLNTLRYADR VKELSPHSGP 540
SGEQLIQMET EEMEACSNGA LIPGNLSKEE EELSSQMSSF NEAMTQIREL EEKAMEELKE 600
IIQQGPDWLE LSEMTEQPDY DLETFVNKAE SALAQQAKHF SALRDVIKAL RLAMQLEEQA 660
SRQISSKKRP Q 671 
Gene Ontology
 GO:0000775; C:chromosome, centromeric region; IDA:UniProtKB.
 GO:0000777; C:condensed chromosome kinetochore; IEA:UniProtKB-SubCell.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005871; C:kinesin complex; TAS:ProtInc.
 GO:0005874; C:microtubule; IEA:UniProtKB-KW.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0019237; F:centromeric DNA binding; TAS:ProtInc.
 GO:0003777; F:microtubule motor activity; TAS:ProtInc.
 GO:0051010; F:microtubule plus-end binding; IDA:UniProtKB.
 GO:0019886; P:antigen processing and presentation of exogenous peptide antigen via MHC class II; TAS:Reactome.
 GO:0007596; P:blood coagulation; TAS:Reactome.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0008283; P:cell proliferation; TAS:ProtInc.
 GO:0007059; P:chromosome segregation; IEA:UniProtKB-KW.
 GO:0030951; P:establishment or maintenance of microtubule cytoskeleton polarity; IMP:HGNC.
 GO:0007019; P:microtubule depolymerization; IMP:UniProtKB.
 GO:0007018; P:microtubule-based movement; TAS:Reactome.
 GO:0007067; P:mitosis; TAS:ProtInc.
 GO:0000278; P:mitotic cell cycle; TAS:Reactome.
 GO:0051983; P:regulation of chromosome segregation; IMP:UniProtKB. 
Interpro
 IPR019821; Kinesin_motor_CS.
 IPR001752; Kinesin_motor_dom.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00225; Kinesin 
SMART
 SM00129; KISc 
PROSITE
 PS00411; KINESIN_MOTOR_DOMAIN1
 PS50067; KINESIN_MOTOR_DOMAIN2 
PRINTS
 PR00380; KINESINHEAVY.