CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-033920
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha 
Protein Synonyms/Alias
  
Gene Name
 Pip5k1a 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
46SASVMPVKKIGHRSVacetylation[1]
87TVGSLSTKPERDVLMubiquitination[2]
190KEAEFLQKLLPGYYMubiquitination[2]
Reference
 [1] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 497 AA 
Protein Sequence
MASASSGPAA AGFSSLDAGA PAGTAASGIK RATVSEGPSA SVMPVKKIGH RSVDSSGETT 60
YKKTTSSALK GAIQLGITHT VGSLSTKPER DVLMQDFYVV ESIFFPSEGS NLTPAHHYND 120
FRFKTYAPVA FRYFRELFGI RPDDYLYSLC SEPLIELSNS GASGSLFYVS SDDEFIIKTV 180
QHKEAEFLQK LLPGYYMNLN QNPRTLLPKF YGLYCVQAGG KNIRIVVMNN LLPRSVKMHM 240
KYDLKGSTYK RRASQKEREK TLPTFKDLDF LQDIPDGLFL DADMYSALCK TLQRDCLVLQ 300
SFKIMDYSLL MSIHNMDHAQ REPTSNDTQY SADTRRPAPQ KALYSTAMES IQGEARRGGT 360
VETEDHMGGI PARNNKGERL LLYIGIIDIL QSYRFVKKLE HSWKALVHDG DTVSVHRPGF 420
YAERFQRFMC NTVFKKIPYV HLGRPDVLPQ TPPLEEISEG SPVPGPSFSP VVGQPLQILN 480
LSSTLEKLDV AESEFTH 497 
Gene Ontology
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0032587; C:ruffle membrane; IDA:MGI.
 GO:0016308; F:1-phosphatidylinositol-4-phosphate 5-kinase activity; IDA:MGI.
 GO:0010761; P:fibroblast migration; IMP:MGI. 
Interpro
 IPR023610; PInositol-4-P-5-kinase.
 IPR027483; PInositol-4-P-5-kinase_C.
 IPR002498; PInositol-4-P-5-kinase_core.
 IPR027484; PInositol-4-P-5-kinase_N.
 IPR016034; PInositol-4P-5-kinase_core_sub. 
Pfam
 PF01504; PIP5K 
SMART
 SM00330; PIPKc 
PROSITE
 PS51455; PIPK 
PRINTS