CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031633
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein Vil1 
Protein Synonyms/Alias
 Vil1 protein; Villin 1 (Predicted) 
Gene Name
 Vil1 
Gene Synonyms/Alias
 Vil1_predicted; rCG_23932 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
195LRGMTLAKEIRDQERacetylation[1]
254PAAKAALKLYHVSDSacetylation[1]
264HVSDSEGKMVVREVAacetylation[1]
299GLKIFVWKGKNANAQacetylation[1]
571GDEREMAKMVADTISacetylation[1]
683TTAQEYLKTHPGNRDacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 827 AA 
Protein Sequence
MTKLTAQVKG SLNTTTPGIQ IWRIEAMQMV PVPSSTFGSF FDGDCYVVLA IHKTGSTLSY 60
DIHYWIGQDS SQDEQGAAAI YTTQMDDYLK GRAVQHREVQ GHESDTFRSY FKQGLVIRKG 120
GVASGMKHVE TNSCDVQRLL HVKGKRNVLA GEVEMSWKSF NRGDVFLLDL GKLIIQWNGP 180
ESNRMERLRG MTLAKEIRDQ ERGGRTYVGV VDGENEGDSP QLMAIMNHVL GPRKELKAAI 240
SDSVVEPAAK AALKLYHVSD SEGKMVVREV ATQPLTQDLL SHEDCYILDQ GGLKIFVWKG 300
KNANAQERSG AMNQALNFIK AKQYPPSTQV EVQNDGAESA IFQQLFQKWT VPNRTSGLGK 360
THTVGSVAKV EQVKFDALSM HVRPQVAAQQ KMVDDGSGEV QVWRIEDLEL VPVESKWLGH 420
FYGGDCYLLL YTYLIGEKEH YLLYIWQGSQ ASQDEIAASA YQAVNLDQKY NDEPVQIRVT 480
MGKEPPHLMS IFKGRMVVYQ GGTSRKNNVE PVPSTRLFQV RGTSADNTKA FEVTARATSL 540
NSNDVFILKT PSCCYLWCGK GCSGDEREMA KMVADTISRT EKQVVVEGQE PANFWMALGG 600
KAPYANTKRL QEENQVITPR LFECSNQTGR FLATEIFDFT QDDLEEDDVF LLDVWDQVFF 660
WIGKHANEEE KKAAATTAQE YLKTHPGNRD PETPIIVVKQ GHEPSTFTGW FLAWDPFKWS 720
NTKSYDDLKA ELGNSGDWSQ IADEVMSPKV DVFTANTSFS SGPLPIYPLE QLVNKPVEEL 780
PEGVDPTRKE EHLSTEDFTK ALGMTPAAFS ALPRWKQQNL KKEKGLF 827 
Gene Ontology
 GO:0032432; C:actin filament bundle; IEA:Compara.
 GO:0032433; C:filopodium tip; IEA:Compara.
 GO:0030027; C:lamellipodium; IEA:Compara.
 GO:0005902; C:microvillus; IEA:Compara.
 GO:0001726; C:ruffle; IEA:Compara.
 GO:0005509; F:calcium ion binding; IEA:Compara.
 GO:0043027; F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process; IEA:Compara.
 GO:0035727; F:lysophosphatidic acid binding; IEA:Compara.
 GO:0005546; F:phosphatidylinositol-4,5-bisphosphate binding; IEA:Compara.
 GO:0051693; P:actin filament capping; IEA:Compara.
 GO:0030042; P:actin filament depolymerization; IEA:Compara.
 GO:0030041; P:actin filament polymerization; IEA:Compara.
 GO:0051014; P:actin filament severing; IEA:Compara.
 GO:0071364; P:cellular response to epidermal growth factor stimulus; IEA:Compara.
 GO:0035729; P:cellular response to hepatocyte growth factor stimulus; IEA:Compara.
 GO:0060327; P:cytoplasmic actin-based contraction involved in cell motility; IEA:Compara.
 GO:0007173; P:epidermal growth factor receptor signaling pathway; IEA:Compara.
 GO:0032233; P:positive regulation of actin filament bundle assembly; IEA:Compara.
 GO:0010634; P:positive regulation of epithelial cell migration; IEA:Compara.
 GO:0051125; P:regulation of actin nucleation; IEA:Compara.
 GO:0008360; P:regulation of cell shape; IEA:Compara.
 GO:2000392; P:regulation of lamellipodium morphogenesis; IEA:Compara.
 GO:0061041; P:regulation of wound healing; IEA:Compara.
 GO:0009617; P:response to bacterium; IEA:Compara. 
Interpro
 IPR007123; Gelsolin_dom.
 IPR015627; Villin.
 IPR007122; Villin/Gelsolin.
 IPR003128; Villin_headpiece. 
Pfam
 PF00626; Gelsolin
 PF02209; VHP 
SMART
 SM00262; GEL
 SM00153; VHP 
PROSITE
 PS51089; HP 
PRINTS
 PR00597; GELSOLIN.