CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031659
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Cas-Br-M (Murine) ecotropic retroviral transforming sequence b, isoform CRA_a 
Protein Synonyms/Alias
 E3 ubiquitin-protein ligase CBL-B 
Gene Name
 CBLB 
Gene Synonyms/Alias
 hCG_1811662 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
64VRLCQNPKLQLKNSPubiquitination[1]
516PRLDLIQKGIVRSPCubiquitination[1, 2, 3]
531GSPTGSPKSSPCMVRubiquitination[1]
616LLGEGSPKPGITASSubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Metal-binding; Reference proteome; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 810 AA 
Protein Sequence
MANSMNGRNP GGRGGNPRKG RILGIIDAIQ DAVGPPKQAA ADRRTVEKTW KLMDKVVRLC 60
QNPKLQLKNS PPYILDILPD TYQHLRLILS KYDDNQKLAQ LSENEYFKIY IDSLMKKSKR 120
AIRLFKEGKE RMYEEQSQDR RNLTKLSLIF SHMLAEIKAI FPNGQFQGDN FRITKADAAE 180
FWRKFFGDKT IVPWKVFRQC LHEVHQISSG LEAMALKSTI DLTCNDYISV FEFDIFTRLF 240
QPWGSILRNW NFLAVTHPGY MAFLTYDEVK ARLQKYSTKP GSYIFRLSCT RLGQWAIGYV 300
TGDGNILQTI PHNKPLFQAL IDGSREGFYL YPDGRSYNPD LTGLCEPTPH DHIKVTQEQY 360
ELYCEMGSTF QLCKICAEND KDVKIEPCGH LMCTSCLTAW QESDGQGCPF CRCEIKGTEP 420
IIVDPFDPRD EGSRCCSIID PFGMPMLDLD DDDDREESLM MNRLANVRKC TDRQNSPVTS 480
PGSSPLAQRR KPQPDPLQIP HLSLPPVPPR LDLIQKGIVR SPCGSPTGSP KSSPCMVRKQ 540
DKPLPAPPPP LRDPPPPPPE RPPPIPPDNR LSRHIHHVES VPSRDPPMPL EAWCPRDVFG 600
TNQLVGCRLL GEGSPKPGIT ASSNVNGRHS RVGSDPVLMR KHRRHDLPLE GAKVFSNGHL 660
GSEEYDVPPR LSPPPPVTTL LPSIKCTGPL ANSLSEKTRD PVEEDDDEYK IPSSHPVSLN 720
SQPSHCHNVK PPVRSCDNGH CMLNGTHGPS SEKKSNIPDL SIYLKGDVFD SASDPVPLPP 780
ARPPTRDNPK HGSSLNRTPS DYDLLIPPLG 810 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0004871; F:signal transducer activity; IEA:InterPro.
 GO:0004842; F:ubiquitin-protein ligase activity; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
 GO:0006955; P:immune response; IEA:Compara.
 GO:0035556; P:intracellular signal transduction; IEA:Compara.
 GO:0046642; P:negative regulation of alpha-beta T cell proliferation; IEA:Compara.
 GO:0050860; P:negative regulation of T cell receptor signaling pathway; IEA:Compara.
 GO:0045732; P:positive regulation of protein catabolic process; IEA:Compara.
 GO:0002669; P:positive regulation of T cell anergy; IEA:Compara.
 GO:0016567; P:protein ubiquitination; IEA:GOC.
 GO:0042110; P:T cell activation; IEA:Compara. 
Interpro
 IPR024162; Adaptor_Cbl.
 IPR014741; Adaptor_Cbl_EF_hand-like.
 IPR003153; Adaptor_Cbl_N_hlx.
 IPR014742; Adaptor_Cbl_SH2-like.
 IPR024159; Cbl_PTB.
 IPR011992; EF-hand-like_dom.
 IPR000980; SH2.
 IPR001841; Znf_RING.
 IPR013083; Znf_RING/FYVE/PHD.
 IPR017907; Znf_RING_CS. 
Pfam
 PF02262; Cbl_N
 PF02761; Cbl_N2
 PF02762; Cbl_N3 
SMART
 SM00184; RING
 SM00252; SH2 
PROSITE
 PS51506; CBL_PTB
 PS00518; ZF_RING_1
 PS50089; ZF_RING_2 
PRINTS