| Tag | Content |
|---|
| CPLM ID | CPLM-014058 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | General transcription factor II-I |
Protein Synonyms/Alias | GTFII-I; TFII-I |
Gene Name | Gtf2i |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 431 | REDLQLDKPASGVKE | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C- FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box (By similarity). Required for the formation of functional ARID3A DNA-binding complexes and for activation of immunoglobulin heavy-chain transcription upon B- lymphocyte activation (By similarity). |
Sequence Annotation | REPEAT 103 197 GTF2I-like 1.
REPEAT 333 427 GTF2I-like 2.
REPEAT 438 532 GTF2I-like 3.
REPEAT 543 637 GTF2I-like 4.
REPEAT 705 799 GTF2I-like 5.
REPEAT 840 934 GTF2I-like 6.
MOTIF 300 307 Nuclear localization signal (Potential).
MOD_RES 2 2 N-acetylalanine (By similarity).
MOD_RES 103 103 Phosphoserine (By similarity).
MOD_RES 210 210 Phosphoserine (By similarity).
MOD_RES 248 248 Phosphotyrosine; by BTK (By similarity).
MOD_RES 298 298 Phosphotyrosine; by BTK (By similarity).
MOD_RES 379 379 Phosphotyrosine; by BTK (By similarity).
MOD_RES 393 393 Phosphoserine; by PKG/PRKG1 (By
MOD_RES 484 484 Phosphotyrosine; by BTK (By similarity).
MOD_RES 539 539 Phosphothreonine (By similarity).
MOD_RES 649 649 Phosphoserine (By similarity).
MOD_RES 765 765 Phosphoserine; by PKG/PRKG1 (By
MOD_RES 804 804 Phosphoserine (By similarity). |
Keyword | Acetylation; Alternative splicing; Complete proteome; Cytoplasm; DNA-binding; Nucleus; Phosphoprotein; Reference proteome; Repeat; Transcription; Transcription regulation; Ubl conjugation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 979 AA |
Protein Sequence | MAQVAMSALP AEDEESSESR MVVTFLMSAL ESMCKELAKS KAEVACIAVY ETDVFVVGTE 60
RGRAFVNTRK DFQKDFVKYC VEEEEKAAEM HKMKCTTQAN RMSVDAVEIE TLRKTVEDYF 120
CFCYGKALGK STVVPVPYEK MLRDQSAVAV QGLPEGVAFK HPEHYDLATL KWILENKAGI 180
SFIIKRPFLE PKKHLGGRVM AADADRPMLS PGGSCGPIKV KTEPTEDSGI SLEMAAVTVK 240
EESEDPDYYQ YNIQGSHHSS EGNEGAEVEV PAEDSTQHVP SETSEDPEVE VTIEDDDYSP 300
PTKRPKSSEP PPPPPVPEPT NAGKRKVREF NFEKWNARIT DLRKQVEELF ERKYAQAIKA 360
KGPVTIPYPL FQSHVEDLYV EGLPEGIPFR RPSTYGIPRL ERILLAKERI RFVIKKHELL 420
NSTREDLQLD KPASGVKEEW YARITKLRKM VDQLFCKKFA EALGSTEAKA VPYQKFEAYP 480
NDLYVEGLPE NIPFRSPSWY GIPRLEKIIQ VGNRIKFVIK RPELLTHSTT EVTQPRTNTP 540
VKEDWNVRIT KLRKQVEEIF NLKFAQALGL TEAVKVPYPV FESNPEFLYV EGLPEGIPFR 600
SPTWFGIPRL ERIVRGSNKI KFVVKKPELV VSYLPPGMAS KINTKALQSP KRPRSPGSNS 660
KVPEIEVTVE GPNNNSPQTS TVRTPTQTNG SNVPFKPRGR EFSFEAWNAK ITDLKQKVEN 720
LFNEKCGEAL GLKQAVKVPF ALFESFPEDF YVEGLPEGVP FRRPSTFGIP RLEKILRNKA 780
KIKFIIKKPE MFETAIKEST SSKSPPRKTN SSPSVNTTAS GVEDLNIIQV TIPDDDNERL 840
SKVEKARQLR EQVNDLFSRK FGEAIGMGFP VKVPYRKITI NPGCVVVDGM PPGVSFKAPS 900
YLEISSMRRI LDSAEFIKFT VIRPFPGLVI NNQLVDQNES EGPVIQESAE ASQLEVPATE 960
EIKETDGSSQ IKQEPDPTW 979 |
Gene Ontology | GO:0042995; C:cell projection; IEA:Compara. GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0043025; C:neuronal cell body; IEA:Compara. GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0003677; F:DNA binding; IEA:UniProtKB-KW. GO:0009790; P:embryo development; IEA:Compara. GO:0016525; P:negative regulation of angiogenesis; IEA:Compara. GO:0051481; P:reduction of cytosolic calcium ion concentration; IMP:RGD. GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
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