CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-033451
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 CASP8 and FADD-like apoptosis regulator 
Protein Synonyms/Alias
 CASP8 and FADD-like apoptosis regulator, isoform CRA_e 
Gene Name
 CFLAR 
Gene Synonyms/Alias
 hCG_16553 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
154DQLDLLEKCLKNIHRubiquitination[1]
172KTKIQKYKQSVQGAGubiquitination[1]
192VLQAAIQKSLKDPSNubiquitination[1, 2]
195AAIQKSLKDPSNNFRubiquitination[1, 3]
214RSKEQRLKEQLGAQQubiquitination[1]
225GAQQEPVKKSIQESEubiquitination[1]
226AQQEPVKKSIQESEAubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 300 AA 
Protein Sequence
MSAEVIHQVE EALDTDEKEM LLFLCRDVAI DVVPPNVRDL LDILRERGKL SVGDLAELLY 60
RVRRFDLLKR ILKMDRKAVE THLLRNPHLV SDYRVLMAEI GEDLDKSDVS SLIFLMKDYM 120
GRGKISKEKS FLDLVVELEK LNLVAPDQLD LLEKCLKNIH RIDLKTKIQK YKQSVQGAGT 180
SYRNVLQAAI QKSLKDPSNN FRLHNGRSKE QRLKEQLGAQ QEPVKKSIQE SEAFLPQSIP 240
EERYKMKSKP LGICLIIDCI GNETENAHSW IFTLNSMATC MIGTAEFLPR RNIMSGCSTL 300 
Gene Ontology
 GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
 GO:0006508; P:proteolysis; IEA:InterPro.
 GO:0042981; P:regulation of apoptotic process; IEA:InterPro. 
Interpro
 IPR011029; DEATH-like_dom.
 IPR001875; DED.
 IPR002398; Pept_C14_p45. 
Pfam
 PF01335; DED 
SMART
 SM00031; DED 
PROSITE
 PS50168; DED 
PRINTS