CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-000371
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Centrosomal protein of 290 kDa 
Protein Synonyms/Alias
 Cep290; Bardet-Biedl syndrome 14 protein; Cancer/testis antigen 87; CT87; Nephrocystin-6; Tumor antigen se2-2 
Gene Name
 CEP290 
Gene Synonyms/Alias
 BBS14; KIAA0373; NPHP6 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
78NKELEITKEKLHTIEubiquitination[1]
93QAWEQETKLGNESSMubiquitination[1, 2]
102GNESSMDKAKKSITNubiquitination[2]
105SSMDKAKKSITNSDIubiquitination[2]
1382EDLEQQIKILKHVPEubiquitination[2]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
 Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition (By similarity). Activates ATF4-mediated transcription. Required for the correct localization of ciliary and phototransduction proteins in retinal photoreceptor cells; may play a role in ciliary transport processes. 
Sequence Annotation
  
Keyword
 Activator; Alternative splicing; Bardet-Biedl syndrome; Cell projection; Ciliopathy; Cilium; Cilium biogenesis/degradation; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Disease mutation; Joubert syndrome; Leber congenital amaurosis; Meckel syndrome; Mental retardation; Nephronophthisis; Nucleus; Obesity; Polymorphism; Protein transport; Reference proteome; Senior-Loken syndrome; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2479 AA 
Protein Sequence
MAIFKIAALQ KVVDNSVSLS ELELANKQYN ELTAKYRDIL QKDNMLVQRT SNLEHLECEN 60
ISLKEQVESI NKELEITKEK LHTIEQAWEQ ETKLGNESSM DKAKKSITNS DIVSISKKIT 120
MLEMKELNER QRAEHCQKMY EHLRTSLKQM EERNFELETK FAELTKINLD AQKVEQMLRD 180
ELADSVSKAV SDADRQRILE LEKNEMELKV EVSKLREISD IARRQVEILN AQQQSRDKEV 240
ESLRMQLLDY QAQSDEKSLI AKLHQHNVSL QLSEATALGK LESITSKLQK MEAYNLRLEQ 300
KLDEKEQALY YARLEGRNRA KHLRQTIQSL RRQFSGALPL AQQEKFSKTM IQLQNDKLKI 360
MQEMKNSQQE HRNMENKTLE MELKLKGLEE LISTLKDTKG AQKVINWHMK IEELRLQELK 420
LNRELVKDKE EIKYLNNIIS EYERTISSLE EEIVQQNKFH EERQMAWDQR EVDLERQLDI 480
FDRQQNEILN AAQKFEEATG SIPDPSLPLP NQLEIALRKI KENIRIILET RATCKSLEEK 540
LKEKESALRL AEQNILSRDK VINELRLRLP ATAEREKLIA ELGRKEMEPK SHHTLKIAHQ 600
TIANMQARLN QKEEVLKKYQ RLLEKAREEQ REIVKKHEED LHILHHRLEL QADSSLNKFK 660
QTAWDLMKQS PTPVPTNKHF IRLAEMEQTV AEQDDSLSSL LVKLKKVSQD LERQREITEL 720
KVKEFENIKL QLQENHEDEV KKVKAEVEDL KYLLDQSQKE SQCLKSELQA QKEANSRAPT 780
TTMRNLVERL KSQLALKEKQ QKALSRALLE LRAEMTAAAE ERIISATSQK EAHLNVQQIV 840
DRHTRELKTQ VEDLNENLLK LKEALKTSKN RENSLTDNLN DLNNELQKKQ KAYNKILREK 900
EEIDQENDEL KRQIKRLTSG LQGKPLTDNK QSLIEELQRK VKKLENQLEG KVEEVDLKPM 960
KEKNAKEELI RWEEGKKWQA KIEGIRNKLK EKEGEVFTLT KQLNTLKDLF AKADKEKLTL 1020
QRKLKTTGMT VDQVLGIRAL ESEKELEELK KRNLDLENDI LYMRAHQALP RDSVVEDLHL 1080
QNRYLQEKLH ALEKQFSKDT YSKPSISGIE SDDHCQREQE LQKENLKLSS ENIELKFQLE 1140
QANKDLPRLK NQVRDLKEMC EFLKKEKAEV QRKLGHVRGS GRSGKTIPEL EKTIGLMKKV 1200
VEKVQRENEQ LKKASGILTS EKMANIEQEN EKLKAELEKL KAHLGHQLSM HYESKTKGTE 1260
KIIAENERLR KELKKETDAA EKLRIAKNNL EILNEKMTVQ LEETGKRLQF AESRGPQLEG 1320
ADSKSWKSIV VTRMYETKLK ELETDIAKKN QSITDLKQLV KEATEREQKV NKYNEDLEQQ 1380
IKILKHVPEG AETEQGLKRE LQVLRLANHQ LDKEKAELIH QIEANKDQSG AESTIPDADQ 1440
LKEKIKDLET QLKMSDLEKQ HLKEEIKKLK KELENFDPSF FEEIEDLKYN YKEEVKKNIL 1500
LEEKVKKLSE QLGVELTSPV AASEEFEDEE ESPVNFPIY 1539 
Gene Ontology
 GO:0009986; C:cell surface; IDA:UniProtKB.
 GO:0005813; C:centrosome; IDA:UniProtKB.
 GO:0005829; C:cytosol; IDA:HGNC.
 GO:0005932; C:microtubule basal body; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IDA:HGNC.
 GO:0032391; C:photoreceptor connecting cilium; ISS:UniProtKB.
 GO:0036038; C:TCTN-B9D complex; ISS:UniProtKB.
 GO:0042384; P:cilium assembly; ISS:UniProtKB.
 GO:0042462; P:eye photoreceptor cell development; ISS:HGNC.
 GO:0000086; P:G2/M transition of mitotic cell cycle; TAS:Reactome.
 GO:0030902; P:hindbrain development; ISS:HGNC.
 GO:0030916; P:otic vesicle formation; ISS:HGNC.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; IDA:HGNC.
 GO:0048793; P:pronephros development; ISS:HGNC.
 GO:0015031; P:protein transport; ISS:UniProtKB.
 GO:0060041; P:retina development in camera-type eye; IEA:Compara. 
Interpro
 IPR026201; Cep290. 
Pfam
  
SMART
  
PROSITE
  
PRINTS