UniProt Accession

 HDGR3_HUMAN; Q9Y3E1 

Genbank Protein ID

 AB029156; AF110642; AF151900; AK001280; BC015483 

Genbank Nucleotide ID

 BAA90477.1; AAM27001.1; AAD34137.1; BAA91597.1; AAH15483.1 

Protein Name

 Hepatoma-derived growth factor-related protein 3 

Protein Synonyms/Alias

 HRP-3; Hepatoma-derived growth factor 2; HDGF-2 

Gene Name

 HDGFRP3 

Gene Synonyms/Alias

 HDGF2; CGI-142 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
66	PKDLFPYKEYKDKFG	ubiquitination	[1, 2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 

Functional Description

 Enhances DNA synthesis and may play a role in cell proliferation. 

Sequence Annotation

 DOMAIN 11 68 PWWP.
 MOTIF 136 148 Nuclear localization signal (Potential).
 MOD_RES 178 178 Phosphoserine (By similarity).
 MOD_RES 179 179 Phosphoserine (By similarity).
 MOD_RES 180 180 Phosphoserine (By similarity).  

Keyword

 Complete proteome; Growth factor; Nucleus; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 203 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0008283; P:cell proliferation; NAS:UniProtKB. 

Interpro

 IPR000313; PWWP. 

Pfam

 PF00855; PWWP 

SMART

 SM00293; PWWP 

PROSITE

 PS50812; PWWP 

PRINTS