CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015160
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Putative protein arginine N-methyltransferase 10 
Protein Synonyms/Alias
  
Gene Name
 PRMT10 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
126EAAGYFHKAVKLNPDubiquitination[1]
129GYFHKAVKLNPDFSDubiquitination[1]
138NPDFSDAKENFYRVAubiquitination[1]
161FIMLNDTKRNTIYNAubiquitination[1]
172IYNAAIQKAVCLGSKubiquitination[1]
197ILSMFAKKAGAHSVYubiquitination[1]
224CDVVAANKMEAGIKLubiquitination[1]
230NKMEAGIKLLHTKSLubiquitination[1]
235GIKLLHTKSLDIEIPubiquitination[1, 2]
322RHHRVGIKDIAGIHLubiquitination[1]
356IEPYTTEKMSRVPGGubiquitination[2]
752LPCIPLSKPVELLRLubiquitination[1, 3]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
 Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
 J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572] 
Functional Description
  
Sequence Annotation
 REPEAT 25 58 TPR 1.
 REPEAT 67 100 TPR 2.
 REPEAT 101 134 TPR 3.  
Keyword
 Alternative splicing; Complete proteome; Methyltransferase; Polymorphism; Reference proteome; Repeat; TPR repeat; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 845 AA 
Protein Sequence
MSNSRPRSRR DAGGGAGAAG RDELVSRSLQ SAEHCLGVQD FGTAYAHYLL VLSLAPELKH 60
DVKETFQYTL FRWAEELDAL SRIQDLLGCY EQALELFPDD EVICNSMGEH LFRMGFRDEA 120
AGYFHKAVKL NPDFSDAKEN FYRVANWLVE RWHFIMLNDT KRNTIYNAAI QKAVCLGSKS 180
VLDIGAGTGI LSMFAKKAGA HSVYACELSK TMYELACDVV AANKMEAGIK LLHTKSLDIE 240
IPKHIPERVS LVVTETVDAG LFGEGIVESL IHAWEHLLLQ PKTKGESANC EKYGKVIPAS 300
AVIFGMAVEC AEIRRHHRVG IKDIAGIHLP TNVKFQSPAY SSVDTEETIE PYTTEKMSRV 360
PGGYLALTEC FEIMTVDFNN LQELKSLATK KPDKIGIPVI KEGILDAIMV WFVLQLDDEH 420
SLSTSPSEET CWEQAVYPVQ DLADYWIKPG DHVMMEVSCQ DCYLRIQSIS VLGLECEMDV 480
AKSFTQNKDL LSLGNEAELC SALANLQTSK PDAVEQTCIL ESTEIALLNN IPYHEGFKMA 540
MSKVLSSLTP EKLYQTMDTH CQNEMSSGTG QSNTVQNILE PFYVLDVSEG FSVLPVIAGT 600
LGQVKPYSSV EKDQHRIALD LISEANHFPK ETLEFWLRHV EDESAMLQRP KSDKLWSIII 660
LDVIEPSGLI QQEIMEKAAI SRCLLQSGGK IFPQYVLMFG LLVESQTLLE ENAVQGTERT 720
LGLNIAPFIN QFQVPIRVFL DLSSLPCIPL SKPVELLRLD LMTPYLNTSN REVKVYVCKS 780
GRLTAIPFWY HMYLDEEIRL DTSSEASHWK QAAVVLDNPI QVEMGEELVL SIQHHKSNVS 840
ITVKQ 845 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:InterPro.
 GO:0008276; F:protein methyltransferase activity; IEA:InterPro. 
Interpro
 IPR025799; Arg_MeTrfase.
 IPR010456; Ribosomal-L11_MeTrfase_PrmA.
 IPR013026; TPR-contain_dom.
 IPR011990; TPR-like_helical.
 IPR013105; TPR_2.
 IPR019734; TPR_repeat. 
Pfam
 PF06325; PrmA
 PF07719; TPR_2 
SMART
  
PROSITE
 PS50005; TPR
 PS50293; TPR_REGION 
PRINTS