CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-006145
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Lysine-specific permease 
Protein Synonyms/Alias
  
Gene Name
 LYP1 
Gene Synonyms/Alias
 YNL268W; N0790 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
12SNIITSNKWDEKQNNubiquitination[1]
16TSNKWDEKQNNIGEQubiquitination[1, 2]
45EAIDPSNKTTPYSIDubiquitination[1]
54TPYSIDEKQYNTKKKubiquitination[1, 2]
61KQYNTKKKHGSLQGGubiquitination[1]
104EEAHYEDKHVKRALKubiquitination[1, 2]
300PGIISSDKSEGRFLGubiquitination[1]
Reference
 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301]
 [2] Sites of ubiquitin attachment in Saccharomyces cerevisiae.
 Starita LM, Lo RS, Eng JK, von Haller PD, Fields S.
 Proteomics. 2012 Jan;12(2):236-40. [PMID: 22106047] 
Functional Description
 High-affinity permease for lysine. 
Sequence Annotation
 MOD_RES 64 64 Phosphoserine.
 MOD_RES 75 75 Phosphoserine.
 MOD_RES 77 77 Phosphothreonine.
 MOD_RES 79 79 Phosphoserine.
 MOD_RES 87 87 Phosphoserine.
 MOD_RES 90 90 Phosphothreonine.  
Keyword
 Amino-acid transport; Complete proteome; Membrane; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 611 AA 
Protein Sequence
MGRFSNIITS NKWDEKQNNI GEQSMQELPE DQIEHEMEAI DPSNKTTPYS IDEKQYNTKK 60
KHGSLQGGAI ADVNSITNSL TRLQVVSHET DINEDEEEAH YEDKHVKRAL KQRHIGMIAL 120
GGTIGTGLFV GISTPLSNAG PVGSLIAYIF MGTIVYFVTQ SLGEMATFIP VTSSITVFSK 180
RFLSPAFGVS NGYMYWFNWA ITYAVEVSVI GQVIEYWTDK VPLAAWIAIF WVIITLMNFF 240
PVKVYGEFEF WVASVKVLAI MGYLIYALII VCGGSHQGPI GFRYWRNPGA WGPGIISSDK 300
SEGRFLGWVS SLINAAFTYQ GTELVGITAG EAANPRKTVP RAINKVVFRI VLFYIMSLFF 360
IGLLVPYNDS RLSASSAVIA SSPFVISIQN AGTYALPDIF NAVVLITVVS AANSNVYVGS 420
RVLYSLARTG NAPKQFGYVT RQGVPYLGVV CTAALGLLAF LVVNNNANTA FNWLINISTL 480
AGLCAWLFIS LAHIRFMQAL KHRGISRDDL PFKAKLMPYG AYYAAFFVTV IIFIQGFQAF 540
CPFKVSEFFT SYISLILLAV VFIGCQIYYK CRFIWKLEDI DIDSDRREIE AIIWEDDEPK 600
NLWEKFWAAV A 611 
Gene Ontology
 GO:0016021; C:integral to membrane; ISM:SGD.
 GO:0005739; C:mitochondrion; IDA:SGD.
 GO:0005886; C:plasma membrane; ISS:SGD.
 GO:0015174; F:basic amino acid transmembrane transporter activity; IDA:SGD. 
Interpro
 IPR004841; AA-permease_dom.
 IPR002293; AA/rel_permease1.
 IPR004762; Amino_acid_permease_fungi.
 IPR004840; Amoino_acid_permease_CS. 
Pfam
 PF00324; AA_permease 
SMART
  
PROSITE
 PS00218; AMINO_ACID_PERMEASE_1 
PRINTS