CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-008047
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Interferon alpha/beta receptor 2 
Protein Synonyms/Alias
 IFN-R-2; IFN-alpha binding protein; IFN-alpha/beta receptor 2; Interferon alpha binding protein; Type I interferon receptor 2 
Gene Name
 IFNAR2 
Gene Synonyms/Alias
 IFNABR; IFNARB 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
286VLRQGLAKGWNAVAIubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961
Functional Description
 Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation. Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1. Isoform 3 is a potent inhibitor of type I IFN receptor activity. 
Sequence Annotation
 MOD_RES 400 400 Phosphoserine (By similarity).
 CARBOHYD 58 58 N-linked (GlcNAc...) (Potential).
 CARBOHYD 87 87 N-linked (GlcNAc...).
 CARBOHYD 116 116 N-linked (GlcNAc...) (Potential).
 CARBOHYD 188 188 N-linked (GlcNAc...) (Potential).
 CARBOHYD 192 192 N-linked (GlcNAc...).
 DISULFID 39 122
 DISULFID 85 93
 DISULFID 207 227  
Keyword
 3D-structure; Alternative splicing; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Membrane; Phosphoprotein; Polymorphism; Receptor; Reference proteome; Secreted; Signal; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 515 AA 
Protein Sequence
MLLSQNAFIF RSLNLVLMVY ISLVFGISYD SPDYTDESCT FKISLRNFRS ILSWELKNHS 60
IVPTHYTLLY TIMSKPEDLK VVKNCANTTR SFCDLTDEWR STHEAYVTVL EGFSGNTTLF 120
SCSHNFWLAI DMSFEPPEFE IVGFTNHINV MVKFPSIVEE ELQFDLSLVI EEQSEGIVKK 180
HKPEIKGNMS GNFTYIIDKL IPNTNYCVSV YLEHSDEQAV IKSPLKCTLL PPGQESESAE 240
SAKIGGIITV FLIALVLTST IVTLKWIGYI CLRNSLPKVL RQGLAKGWNA VAIHRCSHNA 300
LQSETPELKQ SSCLSFPSSW DYKRASLCPS D 331 
Gene Ontology
 GO:0005576; C:extracellular region; TAS:ProtInc.
 GO:0005615; C:extracellular space; IDA:UniProtKB.
 GO:0005887; C:integral to plasma membrane; IDA:UniProtKB.
 GO:0004905; F:type I interferon receptor activity; IDA:UniProtKB.
 GO:0008283; P:cell proliferation; IEA:Compara.
 GO:0007259; P:JAK-STAT cascade; TAS:ProtInc.
 GO:0006357; P:regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0060338; P:regulation of type I interferon-mediated signaling pathway; TAS:Reactome.
 GO:0035455; P:response to interferon-alpha; IDA:UniProtKB.
 GO:0009615; P:response to virus; TAS:ProtInc.
 GO:0060337; P:type I interferon-mediated signaling pathway; TAS:Reactome. 
Interpro
 IPR003961; Fibronectin_type3.
 IPR013783; Ig-like_fold.
 IPR015373; Interferon_alpha/beta_rcpt_bsu. 
Pfam
 PF09294; Interfer-bind 
SMART
  
PROSITE
  
PRINTS