CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-025469
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Meiotic recombination 11 homolog A (S. cerevisiae), isoform CRA_c 
Protein Synonyms/Alias
  
Gene Name
 Mre11a 
Gene Synonyms/Alias
 mCG_22656 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
443QYFQTAEKNVQLSLLubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 DNA damage; DNA repair; Endonuclease; Exonuclease; Hydrolase; Manganese; Meiosis; Nuclease; Nucleus. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 706 AA 
Protein Sequence
MSPTDPLDDE DTFKILVATD IHLGFMEKDA VRGNDTFVTF DEILRLALEN EVDFILLGGD 60
LFHENKPSRK TLHSCLELLR KYCMGDRPVQ FEVISDQSVN FGFSKFPWVN YQDGNLNISI 120
PVFSIHGNHD DPTGADALCA LDVLSCAGFV NHFGRSMSVE KVDISPVLLQ KGSTKLALYG 180
LGSIPDERLY RMFVNKKVTM LRPKEDENSW FNLFVIHQNR SKHGNTNFIP EQFLDDFIDL 240
VIWGHEHECK IGPIKNEQQL FYVSQPGSSV VTSLSPGEAV KKHVGLLRIK GRKMNMQKLP 300
LRTVRRFFIE DVVLANHPNL FNPDNPKVTQ AIQSFCLEKI EEMLDSAERE RLGNPQQPGK 360
PLIRLRVDYS GGFEPFNVLR FSQKFVDRVA NPKDVIHFFR HREQKGKTGE EINFGMLITK 420
PASEGATLRV EDLVKQYFQT AEKNVQLSLL TERGMGEAVQ EFVDKEEKDA IEELVKYQLE 480
KTQRFLKERH IDALEDKIDE EVRRFRESRQ RNTNEEDDEV REAMSRARAL RSQSETSTSA 540
FSAEDLSFDT SEQTANDSDD SLSAVPSRGR GRGRGRRGAR GQSSAPRGGS QRGRDTGLEI 600
TTRGRSSKAT SSTSRNMSII DAFRSTRQQP SRNVAPKNYS ETIEVDDSDE DDIFPTNSRA 660
DQRWSGTTSS KRMSQSQTAK GVDFESDEDD DDDPFMSSSC PRRNRR 706 
Gene Ontology
 GO:0000781; C:chromosome, telomeric region; IEA:Compara.
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0004003; F:ATP-dependent DNA helicase activity; IEA:Compara.
 GO:0003677; F:DNA binding; IEA:Compara.
 GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
 GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
 GO:0030145; F:manganese ion binding; IEA:InterPro.
 GO:0008283; P:cell proliferation; IMP:MGI.
 GO:0006302; P:double-strand break repair; IMP:MGI.
 GO:0031573; P:intra-S DNA damage checkpoint; IMP:MGI.
 GO:0007095; P:mitotic G2 DNA damage checkpoint; IMP:MGI.
 GO:0032876; P:negative regulation of DNA endoreduplication; IEA:Compara.
 GO:0090305; P:nucleic acid phosphodiester bond hydrolysis; IEA:GOC.
 GO:0033674; P:positive regulation of kinase activity; IEA:Compara.
 GO:0031954; P:positive regulation of protein autophosphorylation; IEA:Compara.
 GO:0007062; P:sister chromatid cohesion; IEA:Compara.
 GO:0007129; P:synapsis; IMP:MGI. 
Interpro
 IPR003701; DNA_repair_Mre11.
 IPR004843; Metallo_PEstase_dom.
 IPR007281; Mre11_DNA-bd. 
Pfam
 PF00149; Metallophos
 PF04152; Mre11_DNA_bind 
SMART
  
PROSITE
  
PRINTS