CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038720
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Axin-1 
Protein Synonyms/Alias
  
Gene Name
 Axin1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
522GHGKHVPKLGLKLDTacetylation[1]
Reference
 [1] The fasted/fed mouse metabolic acetylome: N6-acetylation differences suggest acetylation coordinates organ-specific fuel switching.
 Yang L, Vaitheesvaran B, Hartil K, Robinson AJ, Hoopmann MR, Eng JK, Kurland IJ, Bruce JE.
 J Proteome Res. 2011 Sep 2;10(9):4134-49. [PMID: 21728379
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 868 AA 
Protein Sequence
MQSPKMNVQE QGFPLDLGAS FTEDAPRPPV PGEEGELVST DSRPVNHSFC SGKGTSIKSE 60
TSTATPRRSD LDLGYEPEGS ASPTPPYLRW AESLHSLLDD QDGISLFRTF LKQEGCADLL 120
DFWFACSGFR KLEPCDSNEE KRLKLARAIY RKYILDSNGI VSRQTKPATK SFIKDCVMKQ 180
QIDPAMFDQA QTEIQSTMEE NTYPSFLKSD IYLEYTRTGS ESPKVCSDQS SGSGTGKGMS 240
GYLPTLNEDE EWKCDQDADE DDGRDPLPPS RLTQKLLLET AAPRAPSSRR YNEGRELRYG 300
SWREPVNPYY VNSGYALAPA TSANDSEQQS LSSDADTLSL TDSSVDGIPP YRIRKQHRRE 360
MQESIQVNGR VPLPHIPRTY RMPKEIRVEP QKFAEELIHR LEAVQRTREA EEKLEERLKR 420
VRMEEEGEDG EMPSGPMASH KLPSVPAWHH FPPRYVDMGC SGLRDAHEEN PESILDEHVQ 480
RVMRTPGCQS PGPGHRSPDS GHVAKTAVLG GTASGHGKHV PKLGLKLDTA GLHHHRHVHH 540
HVHHNSARPK EQMEAEVARR VQSSFSWGPE THGHAKPRSY SENAGTTLSA GDLAFGGKTS 600
APSKRNTKKA ESGKNANAEV PSTTEDAEKN QKIMQWIIEG EKEISRHRKA GHGSSGLRKQ 660
QAHESSRPLS IERPGAVHPW VSAQLRNSVQ PSHLFIQDPT MPPNPAPNPL TQLEEARRRL 720
EEEEKRANKL PSKQRYVQAV MQRGRTCVRP ACAPVLSVVP AVSDLELSET ETKSQRKAGG 780
GSAPPCDSIV VAYYFCGEPI PYRTLVRGRA VTLGQFKELL TKKGSYRYYF KKVSDEFDCG 840
VVFEEVREDE AVLPVFEEKI IGKVEKVD 868 
Gene Ontology
 GO:0030877; C:beta-catenin destruction complex; IDA:MGI.
 GO:0005938; C:cell cortex; IDA:MGI.
 GO:0016023; C:cytoplasmic membrane-bounded vesicle; IDA:MGI.
 GO:0005881; C:cytoplasmic microtubule; IDA:MGI.
 GO:0016328; C:lateral plasma membrane; IEA:Compara.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:Compara.
 GO:0005886; C:plasma membrane; IDA:MGI.
 GO:0014069; C:postsynaptic density; IBA:RefGenome.
 GO:0070016; F:armadillo repeat domain binding; IBA:RefGenome.
 GO:0008013; F:beta-catenin binding; IMP:MGI.
 GO:0005096; F:GTPase activator activity; IBA:RefGenome.
 GO:0002039; F:p53 binding; ISO:MGI.
 GO:0008022; F:protein C-terminus binding; IDA:MGI.
 GO:0019901; F:protein kinase binding; ISO:MGI.
 GO:0004871; F:signal transducer activity; IEA:Compara.
 GO:0007257; P:activation of JUN kinase activity; IBA:RefGenome.
 GO:0048320; P:axial mesoderm formation; IMP:MGI.
 GO:0060823; P:canonical Wnt receptor signaling pathway involved in neural plate anterior/posterior pattern formation; IBA:RefGenome.
 GO:0008219; P:cell death; IBA:RefGenome.
 GO:0043623; P:cellular protein complex assembly; IEA:Compara.
 GO:0071407; P:cellular response to organic cyclic compound; IBA:RefGenome.
 GO:0031122; P:cytoplasmic microtubule organization; IGI:MGI.
 GO:0007368; P:determination of left/right symmetry; IBA:RefGenome.
 GO:0009950; P:dorsal/ventral axis specification; IDA:MGI.
 GO:0048048; P:embryonic eye morphogenesis; IBA:RefGenome.
 GO:0021797; P:forebrain anterior/posterior pattern specification; IBA:RefGenome.
 GO:0071514; P:genetic imprinting; IMP:MGI.
 GO:0001701; P:in utero embryonic development; IMP:MGI.
 GO:0055001; P:muscle cell development; IBA:RefGenome.
 GO:0090090; P:negative regulation of canonical Wnt receptor signaling pathway; IDA:MGI.
 GO:0045599; P:negative regulation of fat cell differentiation; IDA:MGI.
 GO:0051248; P:negative regulation of protein metabolic process; IDA:MGI.
 GO:0034244; P:negative regulation of transcription elongation from RNA polymerase II promoter; IDA:MGI.
 GO:0006913; P:nucleocytoplasmic transport; IDA:MGI.
 GO:0030910; P:olfactory placode formation; IBA:RefGenome.
 GO:0001743; P:optic placode formation; IBA:RefGenome.
 GO:0046330; P:positive regulation of JNK cascade; IMP:MGI.
 GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IEA:Compara.
 GO:0010800; P:positive regulation of peptidyl-threonine phosphorylation; IEA:Compara.
 GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IDA:MGI.
 GO:2000060; P:positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IDA:MGI.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; IEA:Compara.
 GO:0030511; P:positive regulation of transforming growth factor beta receptor signaling pathway; IDA:MGI.
 GO:0051443; P:positive regulation of ubiquitin-protein ligase activity; IEA:Compara.
 GO:0036342; P:post-anal tail morphogenesis; IMP:MGI.
 GO:0030163; P:protein catabolic process; IDA:MGI.
 GO:0051260; P:protein homooligomerization; IDA:MGI.
 GO:0000209; P:protein polyubiquitination; IDA:MGI.
 GO:0035412; P:regulation of catenin import into nucleus; IDA:MGI.
 GO:0007605; P:sensory perception of sound; IMP:MGI.
 GO:0038032; P:termination of G-protein coupled receptor signaling pathway; IEA:InterPro.
 GO:0021881; P:Wnt receptor signaling pathway involved in forebrain neuron fate commitment; IBA:RefGenome.
 GO:0090244; P:Wnt receptor signaling pathway involved in somitogenesis; IBA:RefGenome. 
Interpro
 IPR014936; Axin_b-cat-bd.
 IPR001158; DIX.
 IPR000342; Regulat_G_prot_signal.
 IPR024066; Regulat_G_prot_signal_dom1.
 IPR016137; Regulat_G_prot_signal_superfam. 
Pfam
 PF08833; Axin_b-cat_bind
 PF00778; DIX
 PF00615; RGS 
SMART
 SM00021; DAX
 SM00315; RGS 
PROSITE
 PS50841; DIX
 PS50132; RGS 
PRINTS
 PR01301; RGSPROTEIN.