UniProt Accession

 CRK_HUMAN; P46108; A8MWE8; B0LPE8; D3DTH6; Q96GA9; Q96HJ0 

Genbank Protein ID

 D10656; S65701; BT007277; EU332838; AK291060; AC032044; AC100748; CH471108; CH471108; CH471108; BC001718; BC008506; BC009837 

Genbank Nucleotide ID

 BAA01505.1; AAB28213.1; AAP35941.1; ABY87527.1; BAF83749.1; EAW90621.1; EAW90624.1; EAW90625.1; AAH01718.1; AAH08506.1; AAH09837.1 

Protein Name

 Adapter molecule crk 

Protein Synonyms/Alias

 Proto-oncogene c-Crk; p38 

Gene Name

 CRK 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
253	RVPNAYDKTALALEV	acetylation	[1, 2]

Reference

 [1] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 

Functional Description

 The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity than Crk-I. Crk- II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling. 

Sequence Annotation

 DOMAIN 13 118 SH2.
 DOMAIN 132 192 SH3 1.
 DOMAIN 237 296 SH3 2.
 MOD_RES 41 41 Phosphoserine.
 MOD_RES 42 42 Phosphothreonine (By similarity).
 MOD_RES 74 74 Phosphoserine.
 MOD_RES 83 83 Phosphoserine.
 MOD_RES 221 221 Phosphotyrosine; by ABL1.
 MOD_RES 239 239 Phosphotyrosine.  

Keyword

 3D-structure; Alternative splicing; Cell membrane; Complete proteome; Cytoplasm; Membrane; Phosphoprotein; Proto-oncogene; Reference proteome; Repeat; SH2 domain; SH3 domain. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 304 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005634; C:nucleus; TAS:ProtInc.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0000186; P:activation of MAPKK activity; TAS:Reactome.
 GO:0048013; P:ephrin receptor signaling pathway; IDA:UniProtKB.
 GO:0038096; P:Fc-gamma receptor signaling pathway involved in phagocytosis; TAS:Reactome.
 GO:0045087; P:innate immune response; TAS:Reactome.
 GO:0008286; P:insulin receptor signaling pathway; TAS:Reactome.
 GO:0048011; P:neurotrophin TRK receptor signaling pathway; TAS:Reactome.
 GO:0030168; P:platelet activation; TAS:Reactome.
 GO:0032956; P:regulation of actin cytoskeleton organization; IDA:UniProtKB.
 GO:0035020; P:regulation of Rac protein signal transduction; IEA:Compara.
 GO:0032319; P:regulation of Rho GTPase activity; IDA:UniProtKB.
 GO:0006357; P:regulation of transcription from RNA polymerase II promoter; TAS:ProtInc. 

Interpro

 IPR000980; SH2.
 IPR011511; SH3_2.
 IPR001452; SH3_domain. 

Pfam

 PF00017; SH2
 PF00018; SH3_1
 PF07653; SH3_2 

SMART

 SM00252; SH2
 SM00326; SH3 

PROSITE

 PS50001; SH2
 PS50002; SH3 

PRINTS

 PR00401; SH2DOMAIN.
 PR00452; SH3DOMAIN.