UniProt Accession

 VAMP7_MOUSE; P70280 

Genbank Protein ID

 X96737; AJ133536; AJ133537; AJ133538; AJ133539; AJ133540; AJ133541; AJ133542; AK002825; AK011510; AK089035; AK165299; BC003764 

Genbank Nucleotide ID

 CAA65509.1; CAB94231.1; CAB94231.1; CAB94231.1; CAB94231.1; CAB94231.1; CAB94231.1; CAB94231.1; BAB22386.1; BAB27667.1; BAC40712.1; BAE38126.1; AAH03764.1 

Protein Name

 Vesicle-associated membrane protein 7 

Protein Synonyms/Alias

 VAMP-7; Synaptobrevin-like protein 1 

Gene Name

 Vamp7 

Gene Synonyms/Alias

 Sybl1 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
115	SVLAAQLKHHSENKS	ubiquitination	[1]
125	SENKSLDKVMETQAQ	ubiquitination	[1]
137	QAQVDELKGIMVRNI	ubiquitination	[1]
160	RLELLIDKTENLVDS	ubiquitination	[1]
172	VDSSVTFKTTSRNLA	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for exocytosis of mediators during eosinophil and neutrophil degranulation, and target cell killing by natural killer cells. Required for focal exocytosis of late endocytic vesicles during phagosome formation. 

Sequence Annotation

 DOMAIN 7 110 Longin.
 DOMAIN 125 185 v-SNARE coiled-coil homology.
 MOD_RES 2 2 N-acetylalanine (By similarity).  

Keyword

 3D-structure; Acetylation; Cell junction; Coiled coil; Complete proteome; Cytoplasmic vesicle; Endoplasmic reticulum; Endosome; Exocytosis; Golgi apparatus; Lysosome; Membrane; Protein transport; Reference proteome; Signal-anchor; Synapse; Synaptosome; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 220 AA 

Protein Sequence

Gene Ontology

 GO:0045177; C:apical part of cell; IDA:MGI.
 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0005789; C:endoplasmic reticulum membrane; ISS:UniProtKB.
 GO:0005794; C:Golgi apparatus; IDA:MGI.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0031902; C:late endosome membrane; ISS:UniProtKB.
 GO:0005765; C:lysosomal membrane; ISS:UniProtKB.
 GO:0043005; C:neuron projection; IDA:UniProtKB.
 GO:0048471; C:perinuclear region of cytoplasm; IDA:MGI.
 GO:0045335; C:phagocytic vesicle; IDA:UniProtKB.
 GO:0030670; C:phagocytic vesicle membrane; IEA:UniProtKB-SubCell.
 GO:0031201; C:SNARE complex; ISS:UniProtKB.
 GO:0045202; C:synapse; IEA:UniProtKB-KW.
 GO:0030658; C:transport vesicle membrane; IEA:UniProtKB-SubCell.
 GO:0017156; P:calcium ion-dependent exocytosis; ISS:UniProtKB.
 GO:0008333; P:endosome to lysosome transport; ISS:UniProtKB.
 GO:0043308; P:eosinophil degranulation; ISS:UniProtKB.
 GO:0006888; P:ER to Golgi vesicle-mediated transport; ISS:UniProtKB.
 GO:0043001; P:Golgi to plasma membrane protein transport; IMP:MGI.
 GO:0043312; P:neutrophil degranulation; ISS:UniProtKB.
 GO:0006911; P:phagocytosis, engulfment; ISS:UniProtKB.
 GO:1900483; P:regulation of protein targeting to vacuolar membrane; IMP:MGI.
 GO:0034197; P:triglyceride transport; IEA:Compara.
 GO:0006906; P:vesicle fusion; ISS:UniProtKB.
 GO:0048280; P:vesicle fusion with Golgi apparatus; IEA:Compara. 

Interpro

 IPR011012; Longin-like_dom.
 IPR010908; Longin_dom.
 IPR001388; Synaptobrevin. 

Pfam

 PF13774; Longin
 PF00957; Synaptobrevin 

SMART

  

PROSITE

 PS50859; LONGIN
 PS00417; SYNAPTOBREVIN
 PS50892; V_SNARE 

PRINTS

 PR00219; SYNAPTOBREVN.