CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019042
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Solute carrier family 25 member 46 
Protein Synonyms/Alias
  
Gene Name
 SLC25A46 
Gene Synonyms/Alias
 TB1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
60RNLHWGEKSPPYGVPubiquitination[1, 2]
193LPREVLHKWSPKQIGubiquitination[1]
197VLHKWSPKQIGEHLLubiquitination[1, 3, 4]
241TGILECVKEGIGRVIubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
  
Sequence Annotation
 REPEAT 96 187 Solcar 1.
 REPEAT 311 413 Solcar 2.
 MOD_RES 45 45 Phosphothreonine.  
Keyword
 Complete proteome; Membrane; Mitochondrion; Mitochondrion inner membrane; Phosphoprotein; Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 418 AA 
Protein Sequence
MHPRRPDGFD GLGYRGGARD EQGFGGAFPA RSFSTGSDLG HWVTTPPDIP GSRNLHWGEK 60
SPPYGVPTTS TPYEGPTEEP FSSGGGGSVQ GQSSEQLNRF AGFGIGLASL FTENVLAHPC 120
IVLRRQCQVN YHAQHYHLTP FTVINIMYSF NKTQGPRALW KGMGSTFIVQ GVTLGAEGII 180
SEFTPLPREV LHKWSPKQIG EHLLLKSLTY VVAMPFYSAS LIETVQSEII RDNTGILECV 240
KEGIGRVIGM GVPHSKRLLP LLSLIFPTVL HGVLHYIISS VIQKFVLLIL KRKTYNSHLA 300
ESTSPVQSML DAYFPELIAN FAASLCSDVI LYPLETVLHR LHIQGTRTII DNTDLGYEVL 360
PINTQYEGMR DCINTIRQEE GVFGFYKGFG AVIIQYTLHA AVLQITKIIY STLLQNNI 418 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
 GO:0006810; P:transport; IEA:UniProtKB-KW. 
Interpro
 IPR018108; Mitochondrial_sb/sol_carrier.
 IPR023395; Mt_carrier_dom. 
Pfam
 PF00153; Mito_carr 
SMART
  
PROSITE
 PS50920; SOLCAR 
PRINTS