| Tag | Content |
|---|
| CPLM ID | CPLM-014588 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial |
Protein Synonyms/Alias | Complex I-49kD; CI-49kD; NADH-ubiquinone oxidoreductase 49 kDa subunit |
Gene Name | Ndufs2 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 62 | SKETAHWKPPPWNDV | acetylation | [1] | | 73 | WNDVDVLKEKVVTNV | acetylation | [1] | | 372 | PPKRAEMKTSMESLI | acetylation | [1] | | 437 | AHLAGLDKMSKGHML | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). |
Sequence Annotation | METAL 326 326 Iron-sulfur (4Fe-4S) (Potential).
METAL 332 332 Iron-sulfur (4Fe-4S) (Potential).
METAL 347 347 Iron-sulfur (4Fe-4S) (Potential). |
Keyword | 4Fe-4S; Complete proteome; Electron transport; Iron; Iron-sulfur; Membrane; Metal-binding; Mitochondrion; Mitochondrion inner membrane; NAD; Oxidoreductase; Reference proteome; Respiratory chain; Transit peptide; Transport; Ubiquinone. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 463 AA |
Protein Sequence | MAALRAVCSL RGVGAQVLRA GSGIRLPSQP SRGARRWQPD IEWAEQFSGA VMYPSKETAH 60
WKPPPWNDVD VLKEKVVTNV TLNFGPQHPA AHGVLRLVLE LSGEMVRKCD PHIGLLHRGT 120
EKLIEYKTYL QALPYFDRLD YVSMMCNEQA YSLAVEKLLN IQPPPRAQWI RVLFGEITRI 180
LNHIMAVTTH ALDIGAMTPF FWMFEEREKM FEFYERVSGA RMHAAYIRPG GVHQDLPLGL 240
MDDIYEFSKN FSLRIDEVEE MLTNNRIWRN RTVDIGVVSA EDALNYGFSG VMLRGSGIQW 300
DLRKTQPYDV YDQVEFDVPI GSRGDCYDRY LCRVEEMRQS LRIIEQCLNK MPPGEIKVDD 360
AKVSPPKRAE MKTSMESLIH HFKLYTEGYQ VPPGATYTAI EAPKGEFGVY LVSDGSSRPY 420
RCKIKAPGFA HLAGLDKMSK GHMLADVVAI IGTQDIVFGE IDR 463 |
Gene Ontology | GO:0005747; C:mitochondrial respiratory chain complex I; IEA:Compara. GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0051287; F:NAD binding; IEA:InterPro. GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:EC. GO:0048038; F:quinone binding; IEA:InterPro. GO:0022900; P:electron transport chain; IEA:UniProtKB-KW. GO:0006979; P:response to oxidative stress; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |