CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-027083
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Gap junction protein 
Protein Synonyms/Alias
  
Gene Name
 Gja1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
9GDWSALGKLLDKVQAubiquitination[1]
108RKEEKLNKKEEELKVubiquitination[1]
109KEEKLNKKEEELKVAubiquitination[1]
114NKKEEELKVAQTDGVubiquitination[1]
128VNVEMHLKQIEIKKFubiquitination[1]
136QIEIKKFKYGIEEHGubiquitination[1]
144YGIEEHGKVKMRGGLubiquitination[1]
258TGPLSPSKDCGSPKYubiquitination[1]
264SKDCGSPKYAYFNGCubiquitination[1]
303SSCRNYNKQASEQNWubiquitination[1]
345PDDSQNAKKVAAGHEubiquitination[1]
346DDSQNAKKVAAGHELubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell (By similarity). 
Sequence Annotation
  
Keyword
 Cell junction; Cell membrane; Gap junction; Membrane; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 434 AA 
Protein Sequence
MGDWSALGKL LDKVQAYSTA GGKVWLSVLF IFRILLLGTA VESAWGDEQS AFRCNTQQPG 60
CENVCYDKSF PISHVRFWVL QIIFVSVPTL LYLAHVFYVM RKEEKLNKKE EELKVAQTDG 120
VNVEMHLKQI EIKKFKYGIE EHGKVKMRGG LLRTYIISIL FKSVFEVAFL LIQWYIYGFS 180
LSAVYTCKRD PCPHQVDCFL SRPTEKTIFI IFMLVVSLVS LALNIIELFY VFFKGVKDRV 240
KGRSDPYHAT TGPLSPSKDC GSPKYAYFNG CSSPTAPLSP MSPPGYKLVT GDRNNSSCRN 300
YNKQASEQNW ANYSAEQNRM GQAGSTISNS HAQPFDFPDD SQNAKKVAAG HELQPLAIVD 360
QRPSSRASSR ASSRPRPDDL EILNRLEHQA ANRLWRRKKR VLAERAPGVF ISFPWRWYST 420
TSVMRRRKQR HYNI 434 
Gene Ontology
 GO:0016324; C:apical plasma membrane; IDA:MGI.
 GO:0005922; C:connexon complex; IEA:InterPro.
 GO:0043292; C:contractile fiber; IDA:MGI.
 GO:0005829; C:cytosol; IDA:MGI.
 GO:0005769; C:early endosome; IEA:Compara.
 GO:0005916; C:fascia adherens; IDA:MGI.
 GO:0005921; C:gap junction; IDA:MGI.
 GO:0005794; C:Golgi apparatus; IDA:MGI.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0016328; C:lateral plasma membrane; IDA:MGI.
 GO:0005764; C:lysosome; IEA:Compara.
 GO:0045121; C:membrane raft; IEA:Compara.
 GO:0005741; C:mitochondrial outer membrane; IEA:Compara.
 GO:0005771; C:multivesicular body; IEA:Compara.
 GO:0048487; F:beta-tubulin binding; IDA:MGI.
 GO:0005243; F:gap junction channel activity; IDA:MGI.
 GO:0004871; F:signal transducer activity; IEA:Compara.
 GO:0007512; P:adult heart development; IMP:MGI.
 GO:0006915; P:apoptotic process; IMP:MGI.
 GO:0015867; P:ATP transport; IEA:Compara.
 GO:0003294; P:atrial ventricular junction remodeling; IGI:MGI.
 GO:0048514; P:blood vessel morphogenesis; IMP:MGI.
 GO:0061337; P:cardiac conduction; IMP:MGI.
 GO:0010643; P:cell communication by chemical coupling; IDA:MGI.
 GO:0010644; P:cell communication by electrical coupling; IDA:MGI.
 GO:0045216; P:cell-cell junction organization; IMP:MGI.
 GO:0007267; P:cell-cell signaling; IDA:MGI.
 GO:0002070; P:epithelial cell maturation; IMP:MGI.
 GO:0001947; P:heart looping; IMP:MGI.
 GO:0001701; P:in utero embryonic development; IMP:MGI.
 GO:0002088; P:lens development in camera-type eye; IMP:MGI.
 GO:0060174; P:limb bud formation; IMP:MGI.
 GO:0060156; P:milk ejection; IMP:MGI.
 GO:0008285; P:negative regulation of cell proliferation; IEA:Compara.
 GO:0010629; P:negative regulation of gene expression; IMP:MGI.
 GO:0001764; P:neuron migration; IMP:MGI.
 GO:0048812; P:neuron projection morphogenesis; IEA:Compara.
 GO:0001649; P:osteoblast differentiation; IMP:MGI.
 GO:0010628; P:positive regulation of gene expression; IMP:MGI.
 GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; IEA:Compara.
 GO:0045732; P:positive regulation of protein catabolic process; IEA:Compara.
 GO:0045844; P:positive regulation of striated muscle tissue development; IMP:MGI.
 GO:0051259; P:protein oligomerization; IEA:Compara.
 GO:0060371; P:regulation of atrial cardiac muscle cell membrane depolarization; IMP:MGI.
 GO:0030500; P:regulation of bone mineralization; IMP:MGI.
 GO:0046850; P:regulation of bone remodeling; IMP:MGI.
 GO:0051924; P:regulation of calcium ion transport; IEA:Compara.
 GO:2000810; P:regulation of tight junction assembly; IEA:Compara.
 GO:0060373; P:regulation of ventricular cardiac muscle cell membrane depolarization; IMP:MGI.
 GO:0060307; P:regulation of ventricular cardiac muscle cell membrane repolarization; IMP:MGI.
 GO:0043434; P:response to peptide hormone stimulus; IEA:Compara.
 GO:0009268; P:response to pH; IEA:Compara.
 GO:0043403; P:skeletal muscle tissue regeneration; IDA:MGI.
 GO:0010232; P:vascular transport; IEA:Compara. 
Interpro
 IPR000500; Connexin.
 IPR002261; Connexin43.
 IPR013124; Connexin43_C.
 IPR019570; Connexin_CCC.
 IPR017990; Connexin_CS.
 IPR013092; Connexin_N. 
Pfam
 PF00029; Connexin
 PF03508; Connexin43
 PF10582; Connexin_CCC 
SMART
 SM00037; CNX
 SM01089; Connexin_CCC 
PROSITE
 PS00407; CONNEXINS_1
 PS00408; CONNEXINS_2 
PRINTS
 PR00206; CONNEXIN.
 PR01132; CONNEXINA1.