CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-002577
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Ornithine aminotransferase 
Protein Synonyms/Alias
 Ornithine--oxo-acid aminotransferase 
Gene Name
 CAR2 
Gene Synonyms/Alias
 CARGB; YLR438W; L9753.2 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
32PLPVVFHKAKGAHVWacetylation[1]
346QLKALQAKSNGIISEubiquitination[2]
390KDHGLLAKPTHDHIIacetylation[1]
390KDHGLLAKPTHDHIIubiquitination[2, 3]
Reference
 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, VillĂ©n J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301]
 [3] Sites of ubiquitin attachment in Saccharomyces cerevisiae.
 Starita LM, Lo RS, Eng JK, von Haller PD, Fields S.
 Proteomics. 2012 Jan;12(2):236-40. [PMID: 22106047
Functional Description
  
Sequence Annotation
 MOD_RES 272 272 N6-(pyridoxal phosphate)lysine (By  
Keyword
 Aminotransferase; Complete proteome; Cytoplasm; Pyridoxal phosphate; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 424 AA 
Protein Sequence
MSEATLSSKQ TIEWENKYSA HNYHPLPVVF HKAKGAHVWD PEGKLYLDFL SAYSAVNQGH 60
CHPHIIKALT EQAQTLTLSS RAFHNDVYAQ FAKFVTEFFG FETVLPMNTG AEAVETALKL 120
ARRWGYMKKN IPQDKAIILG AEGNFHGRTF GAISLSTDYE DSKLHFGPFV PNVASGHSVH 180
KIRYGHAEDF VPILESPEGK NVAAIILEPI QGEAGIVVPP ADYFPKVSAL CRKHNVLLIV 240
DEIQTGIGRT GELLCYDHYK AEAKPDIVLL GKALSGGVLP VSCVLSSHDI MSCFTPGSHG 300
STFGGNPLAS RVAIAALEVI RDEKLCQRAA QLGSSFIAQL KALQAKSNGI ISEVRGMGLL 360
TAIVIDPSKA NGKTAWDLCL LMKDHGLLAK PTHDHIIRLA PPLVISEEDL QTGVETIAKC 420
IDLL 424 
Gene Ontology
 GO:0005829; C:cytosol; IDA:SGD.
 GO:0005634; C:nucleus; IDA:SGD.
 GO:0004587; F:ornithine-oxo-acid transaminase activity; IMP:SGD.
 GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
 GO:0006527; P:arginine catabolic process; NAS:SGD.
 GO:0055129; P:L-proline biosynthetic process; IEA:UniProtKB-UniPathway.
 GO:0006591; P:ornithine metabolic process; IMP:SGD. 
Interpro
 IPR005814; Aminotrans_3.
 IPR010164; Orn_aminotrans.
 IPR015424; PyrdxlP-dep_Trfase.
 IPR015421; PyrdxlP-dep_Trfase_major_sub1.
 IPR015422; PyrdxlP-dep_Trfase_major_sub2. 
Pfam
 PF00202; Aminotran_3 
SMART
  
PROSITE
 PS00600; AA_TRANSFER_CLASS_3 
PRINTS