| Tag | Content |
|---|
| CPLM ID | CPLM-014690 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Coatomer subunit delta |
Protein Synonyms/Alias | Archain; Delta-coat protein; Delta-COP |
Gene Name | Arcn1 |
Gene Synonyms/Alias | Copd |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 233 | LKLGAKGKEVDNFVD | acetylation | [1] | | 309 | MLRISDDKFGRIRLH | acetylation | [1] | | 347 | AESLIGLKNPEKSFP | acetylation | [1] | | 351 | IGLKNPEKSFPVNSD | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). |
Sequence Annotation | DOMAIN 271 511 MHD.
MOD_RES 233 233 N6-acetyllysine (By similarity).
MOD_RES 309 309 N6-acetyllysine (By similarity).
MOD_RES 493 493 Phosphoserine (By similarity). |
Keyword | Acetylation; Complete proteome; Cytoplasm; Cytoplasmic vesicle; ER-Golgi transport; Golgi apparatus; Membrane; Phosphoprotein; Protein transport; Reference proteome; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 511 AA |
Protein Sequence | MVLLAAAVCT KAGKAIVSRQ FVEMTRTRIE GLLAAFPKLM NTGKQHTFVE TESVRYVYQP 60
MEKLYMVLIT TKNSNILEDL ETLRLFSRVI PEYCRALEEN EISEHCFDLI FAFDEIVALG 120
YRENVNLAQI RTFTEMDSHE EKVFRAVRET QEREAKAEMR RKAKELQQAR RDAERQGKKA 180
PGFGGFGSSA VSGGSTAAMI TETIIETDKP KVAPAPARPS GPSKALKLGA KGKEVDNFVD 240
KLKSEGETIM SSNMGKRTSE AAKVHAPPIN MESVHMKIEE KITLTCGRDG GLQNMELHGM 300
IMLRISDDKF GRIRLHVENE DKKGVQLQTH PNVDKKLFTA ESLIGLKNPE KSFPVNSDVG 360
VLKWRLQTTE ESFIPLTINC WPSESGNGCD VNIEYELQED NLELNDVVIT IPLPSGVGAP 420
VIGEIDGEYR HDSRRNTLEW CLPVIDAKNK SGSLEFSIPG QPNDFFPVQV SFISKKNYCN 480
IQVTKVTQVD GNSPVRFSTE TTFLVDKYEI L 511 |
Gene Ontology | GO:0030131; C:clathrin adaptor complex; IEA:InterPro. GO:0030126; C:COPI vesicle coat; IEA:InterPro. GO:0006886; P:intracellular protein transport; IEA:InterPro. GO:0006890; P:retrograde vesicle-mediated transport, Golgi to ER; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |