CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-043637
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Prothrombin 
Protein Synonyms/Alias
  
Gene Name
 F2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
257QDFDPEVKLVENFCRubiquitination[1]
340GLRPLFEKKSLKDTTubiquitination[1]
349SLKDTTEKELLDSYIubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Calcium; Complete proteome; Disulfide bond; Hydrolase; Kringle; Protease; Reference proteome; Serine protease. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 617 AA 
Protein Sequence
MSHVRGLGLP GCLALAALVS LVHSQHVFLA PQQALSLLQR VRRANSGFLE ELRKGNLERE 60
CVEEQCSYEE AFEALESPQD TDVFWAKYTV CDSVRKPRET FMDCLEGRCA MDLGVNYLGT 120
VNVTHTGIQC QLWRSRYPHK PEINSTTHPG ADLKENFCRN PDSSTTGPWC YTTDPTVRRE 180
ECSVPVCQEG RTTVVMTPRS GGSKDNLSPP LGQCLTERGR LYQGNLAVTT LGSPCLPWNS 240
LPAKTLSKYQ DFDPEVKLVE NFCRNPDWDE EGAWCYVAGQ PGDFEYCNLN YCEEAVGEEN 300
YDVDESIAGR TTDAEFHTFF NEKTFGLGEA DCGLRPLFEK KSLKDTTEKE LLDSYIDGRI 360
VEGWDAEKGI APWQVMLFRK SPQELLCGAS LISDRWVLTA AHCILYPPWD KNFTENDLLV 420
RIGKHSRTRY ERNVEKISML EKIYVHPRYN WRENLDRDIA LLKLKKPVPF SDYIHPVCLP 480
DKQTVTSLLR AGYKGRVTGW GNLRETWTTN INEIQPSVLQ VVNLPIVERP VCKASTRIRI 540
TDNMFCAGFK VNDTKRGDAC EGDSGGPFVM KSPFNNRWYQ MGIVSWGEGC DRKGKYGFYT 600
HVFRLKRWIQ KVIDQFG 617 
Gene Ontology
 GO:0005576; C:extracellular region; IEA:InterPro.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0004252; F:serine-type endopeptidase activity; IDA:MGI.
 GO:0030168; P:platelet activation; IDA:MGI.
 GO:0030307; P:positive regulation of cell growth; IGI:MGI.
 GO:0008284; P:positive regulation of cell proliferation; IGI:MGI.
 GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase cascade; IGI:MGI.
 GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
 GO:0008360; P:regulation of cell shape; IGI:MGI.
 GO:0010468; P:regulation of gene expression; IDA:MGI.
 GO:0070493; P:thrombin receptor signaling pathway; ISO:MGI. 
Interpro
 IPR017857; Coagulation_fac_subgr_Gla_dom.
 IPR000294; GLA_domain.
 IPR000001; Kringle.
 IPR013806; Kringle-like.
 IPR018056; Kringle_CS.
 IPR001254; Peptidase_S1.
 IPR018114; Peptidase_S1_AS.
 IPR001314; Peptidase_S1A.
 IPR003966; Prothrombin/thrombin.
 IPR018992; Thrombin_light_chain.
 IPR009003; Trypsin-like_Pept_dom. 
Pfam
 PF00594; Gla
 PF00051; Kringle
 PF09396; Thrombin_light
 PF00089; Trypsin 
SMART
 SM00069; GLA
 SM00130; KR
 SM00020; Tryp_SPc 
PROSITE
 PS00011; GLA_1
 PS50998; GLA_2
 PS00021; KRINGLE_1
 PS50070; KRINGLE_2
 PS50240; TRYPSIN_DOM
 PS00134; TRYPSIN_HIS
 PS00135; TRYPSIN_SER 
PRINTS
 PR00722; CHYMOTRYPSIN.
 PR00001; GLABLOOD.
 PR01505; PROTHROMBIN.