| Tag | Content |
|---|
| CPLM ID | CPLM-024789 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | S-methyl-5'-thioadenosine phosphorylase |
Protein Synonyms/Alias | 5'-methylthioadenosine phosphorylase; MTA phosphorylase; MTAP; MTAPase |
Gene Name | MTAP |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Macaca mulatta (Rhesus macaque) |
NCBI Taxa ID | 9544 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 40 | YVDTPFGKPSDALIL | ubiquitination | [1] | | 71 | QHTIMPSKVNYQANI | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity). |
Sequence Annotation | REGION 60 61 Phosphate binding (By similarity).
REGION 93 94 Phosphate binding (By similarity).
REGION 220 222 Substrate binding (By similarity).
BINDING 18 18 Phosphate (By similarity).
BINDING 196 196 Substrate; via amide nitrogen (By
BINDING 197 197 Phosphate (By similarity). |
Keyword | Complete proteome; Cytoplasm; Glycosyltransferase; Nucleus; Purine salvage; Reference proteome; Transferase. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 283 AA |
Protein Sequence | MASGTTTTAV KIGIIGGTGL DDPEILEGRT EKYVDTPFGK PSDALILGKI KNVDCVLLAR 60
HGRQHTIMPS KVNYQANIWA LKEEGCTHVI VTTACGSLRE EIQPGDIVII DQFIDRTTMR 120
PQSFYDGSHS CARGVCHIPM AEPFCPKTRE VLIETAKKLG LRCHSKGTMV TIEGPRFSSR 180
AESFMFRTWG ADVINMTTVP EVVLAKEAGI CYASIAMATD YDCWKEHEEA VSVDRVLKTL 240
KENANKAKSL LLTTIPQIGS TEWSETLHNL KNMAQFSVLL PRH 283 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0004645; F:phosphorylase activity; IEA:InterPro. GO:0017061; F:S-methyl-5-thioadenosine phosphorylase activity; IEA:HAMAP. GO:0019509; P:L-methionine salvage from methylthioadenosine; IEA:HAMAP. GO:0006166; P:purine ribonucleoside salvage; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |