CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017109
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Zinc finger protein 100 
Protein Synonyms/Alias
  
Gene Name
 ZNF100 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
12RYGMCPLKGASGCPGubiquitination[1, 2]
137AILKKYGKYGHDNLQubiquitination[2]
147HDNLQLQKGCKSVDEubiquitination[2]
236TENSYQCKDCGKAFNubiquitination[2]
240YQCKDCGKAFNWFSTubiquitination[2]
318HTGVKPYKCTECGKAacetylation[3]
318HTGVKPYKCTECGKAubiquitination[2]
324YKCTECGKAFNRSSHubiquitination[2]
343RIIHTGEKPYKCEECubiquitination[2]
346HTGEKPYKCEECGKAubiquitination[2]
374HAGEKPYKCEECGKAubiquitination[2]
380YKCEECGKAFYRFSYubiquitination[2]
390YRFSYLTKHKTSHTGubiquitination[2]
486HTGEKPYKCEECGKAubiquitination[2]
514HTGEKSYKWEECGKDubiquitination[2]
Reference
 [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
 May be involved in transcriptional regulation. 
Sequence Annotation
 DOMAIN 35 107 KRAB.
 ZN_FING 177 199 C2H2-type 1; degenerate.
 ZN_FING 205 227 C2H2-type 2.
 ZN_FING 233 255 C2H2-type 3.
 ZN_FING 261 283 C2H2-type 4.
 ZN_FING 289 311 C2H2-type 5.
 ZN_FING 317 339 C2H2-type 6.
 ZN_FING 345 367 C2H2-type 7.
 ZN_FING 373 395 C2H2-type 8.
 ZN_FING 401 423 C2H2-type 9.
 ZN_FING 429 451 C2H2-type 10.
 ZN_FING 457 479 C2H2-type 11.
 ZN_FING 485 507 C2H2-type 12.  
Keyword
 Complete proteome; DNA-binding; Metal-binding; Nucleus; Polymorphism; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 542 AA 
Protein Sequence
MDDPRYGMCP LKGASGCPGA ERSLLVQSYF EKGPLTFRDV AIEFSLEEWQ CLDSAQQGLY 60
RKVMLENYRN LVFLAGIALT KPDLITCLEQ GKEPWNIKRH EMVAKPPVIC SHFPQDLWAE 120
QDIKDSFQEA ILKKYGKYGH DNLQLQKGCK SVDECKVHKE HDNKLNQCLI TTQSNIFQCD 180
PSAKVFHTFS NSNRHKIRHT RKKPFKCKKC EKSFCMLLHL TQHKRFHITE NSYQCKDCGK 240
AFNWFSTLTT HRRIHTGEKP YKCEECGKAF NRSSHLTTHK IIHTGEKPYR CEECGKAFNR 300
SSHLTTHKRI HTGVKPYKCT ECGKAFNRSS HLTTHRIIHT GEKPYKCEEC GKAFNQSSTL 360
TTHKITHAGE KPYKCEECGK AFYRFSYLTK HKTSHTGEKF YKCEECGKGF NWSSALTKHK 420
RIHTGEKPYK CEECGKAFNE SSNLTTHKMI HTGEKPYKCD ECGKAFNRSS QLTAHKMIHT 480
GEKPYKCEEC GKAFNRSSTL TKHKITHTGE KSYKWEECGK DFNQSLSLIK QNNSYWRETL 540
QM 542 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR001909; Krueppel-associated_box.
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 
Pfam
 PF01352; KRAB 
SMART
 SM00349; KRAB
 SM00355; ZnF_C2H2 
PROSITE
 PS50805; KRAB
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 
PRINTS