| Tag | Content |
|---|
| CPLM ID | CPLM-021784 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Signal peptide peptidase-like 2A |
Protein Synonyms/Alias | SPP-like 2A; SPPL2a; Intramembrane protease 3; IMP-3; Presenilin-like protein 2 |
Gene Name | Sppl2a |
Gene Synonyms/Alias | Imp3; Psl2; MNCb-3763 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 103 | GPCHFLEKARIAQEG | acetylation | [1] |
|
Reference | [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways. Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y. Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [ PMID: 22826441] |
Functional Description | Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in FASLG, ITM2B and TNF processing. Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus. Also responsible for the intramembrane cleavage of Fas antigen ligand FASLG, which promotes the release of the intracellular FasL domain (FasL ICD). May play a role in the regulation of innate and adaptive immunity (By similarity). |
Sequence Annotation | DOMAIN 70 155 PA.
MOTIF 466 468 PAL.
MOTIF 498 501 YXXo lysosomal targeting motif.
ACT_SITE 355 355 By similarity.
ACT_SITE 416 416 By similarity.
CARBOHYD 51 51 N-linked (GlcNAc...) (Potential).
CARBOHYD 61 61 N-linked (GlcNAc...) (Potential).
CARBOHYD 69 69 N-linked (GlcNAc...) (Potential).
CARBOHYD 119 119 N-linked (GlcNAc...) (Potential).
CARBOHYD 129 129 N-linked (GlcNAc...) (Potential).
CARBOHYD 135 135 N-linked (GlcNAc...) (Potential). |
Keyword | Cell membrane; Complete proteome; Endosome; Glycoprotein; Hydrolase; Lysosome; Membrane; Protease; Reference proteome; Signal; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 523 AA |
Protein Sequence | MGLLHSLHAP AAALLWSCLL GLAAAQEAIL HASTNGVSSL SKDYCMYYNN NWTRLPSSLE 60
NATSLSLMNL TGTALCHLSD IPPDGIRNKA VVVHWGPCHF LEKARIAQEG GAAALLIANN 120
SVLIPSSRNK STFQNVTVLI AVITQKDFKD MKETLGDDIT VKMYSPSWPN FDYTLVVIFV 180
IAVFTVALGG YWSGLIELEN MKSVEDAEDR ETRKKKDDYL TFSPLTVVVF VVICCIMIVL 240
LYFFYRWLVY VMIAIFCIAS SMSLYNCLSA LIHRMPCGQC TILCCGKNIK VSLIFLSGLC 300
ISVAVVWAVF RNEDRWAWIL QDILGIAFCL NLIKTMKLPN FMSCVILLGL LLIYDVFFVF 360
ITPFITKNGE SIMVELAAGP FENAEKLPVV IRVPKLMGYS VMSVCSVPVS VLGFGDIIVP 420
GLLIAYCRRF DVQTGSSIYY ISSTIAYAVG MIITFVVLMV MKTGQPALLY LVPCTLITVS 480
VVAWSRKEMK KFWKGSSYQV MDHLDYSTNE ENPVTTDEQI VQQ 523 |
Gene Ontology | GO:0030660; C:Golgi-associated vesicle membrane; ISS:UniProtKB. GO:0071458; C:integral to cytosolic side of endoplasmic reticulum membrane; ISS:UniProtKB. GO:0071556; C:integral to lumenal side of endoplasmic reticulum membrane; ISS:UniProtKB. GO:0031902; C:late endosome membrane; IDA:MGI. GO:0005765; C:lysosomal membrane; IDA:MGI. GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. GO:0004190; F:aspartic-type endopeptidase activity; IEA:InterPro. GO:0042803; F:protein homodimerization activity; ISS:UniProtKB. GO:0006509; P:membrane protein ectodomain proteolysis; ISS:UniProtKB. GO:0031293; P:membrane protein intracellular domain proteolysis; ISS:UniProtKB. GO:0050776; P:regulation of immune response; ISS:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |