UniProt Accession

 LC7L3_HUMAN; O95232; B3KN54; D3DTY1; Q6PHR9; Q9NUY0; Q9P2S7 

Genbank Protein ID

 AB034205; DQ013876; AK001925; AK023672; CH471109; CH471109; CH471109; BC056409; AF069250 

Genbank Nucleotide ID

 BAA90542.1; AAY26238.1; BAA91981.1; BAG51216.1; EAW94583.1; EAW94585.1; EAW94587.1; AAH56409.1; AAC79807.1 

Protein Name

 Luc7-like protein 3 

Protein Synonyms/Alias

 Cisplatin resistance-associated-overexpressed protein; Luc7A; Okadaic acid-inducible phosphoprotein OA48-18; cAMP regulatory element-associated protein 1; CRE-associated protein 1; CREAP-1 

Gene Name

 LUC7L3 

Gene Synonyms/Alias

 CREAP1; CROP; O48 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
23	RNLAPDEKRSNVRWD	ubiquitination	[1]
78	EKSSRFMKVGYERDF	acetylation	[2]
124	GAAGPTGKNEEKIQV	ubiquitination	[3]
166	MKLVEQLKEERELLR	acetylation	[2]
231	KATVEELKEKLRKRT	acetylation	[2]
231	KATVEELKEKLRKRT	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Binds cAMP regulatory element DNA sequence. May play a role in RNA splicing. 

Sequence Annotation

 MOD_RES 1 1 N-acetylmethionine.
 MOD_RES 3 3 Phosphoserine.
 MOD_RES 110 110 Phosphoserine.
 MOD_RES 231 231 N6-acetyllysine.
 MOD_RES 420 420 Phosphoserine.
 MOD_RES 425 425 Phosphoserine.
 MOD_RES 431 431 Phosphoserine.  

Keyword

 Acetylation; Alternative splicing; Coiled coil; Complete proteome; DNA-binding; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 432 AA 

Protein Sequence

Gene Ontology

 GO:0005925; C:focal adhesion; IDA:HPA.
 GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0005886; C:plasma membrane; IDA:HPA.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0003729; F:mRNA binding; IMP:UniProtKB.
 GO:0006915; P:apoptotic process; IMP:UniProtKB.
 GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
 GO:0006950; P:response to stress; IMP:UniProtKB.
 GO:0008380; P:RNA splicing; IMP:UniProtKB. 

Interpro

 IPR004882; LUC7-rel. 

Pfam

 PF03194; LUC7 

SMART

  

PROSITE

  

PRINTS